{"product_id":"nebivolol-hydrochloride-r-65824-s1549","title":"Nebivolol hydrochloride (R-65824)","description":"\u003cp\u003e\u003cstrong\u003eNebivolol hydrochloride (R-65824)\u003c\/strong\u003e is an antagonist of Adrenergic Receptors used in studies of GPCR Signaling and Neurotransmission. In practice, this places the compound in experiments that measure receptor-driven second-messenger signaling and desensitization dynamics and synaptic signaling, receptor activity, and neuronal excitability in cardiovascular and neuroscience models.\u003c\/p\u003e\n\n\u003cp\u003eBy blocking Adrenergic Receptors, Nebivolol hydrochloride (R-65824) can be used to examine receptor-driven second-messenger signaling and desensitization dynamics and synaptic signaling, receptor activity, and neuronal excitability. The gpcr annotation adds relevance to GPCR pharmacology, ligand-binding, and signaling assays, together with downstream-response mapping in the same experimental setting. In cardiovascular and neuroscience models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.\u003c\/p\u003e\n\n\u003ch2\u003eResearch Applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eTarget-focused assays involving Adrenergic Receptors\u003c\/li\u003e\n\u003cli\u003ePathway perturbation studies connected to GPCR Signaling and Neurotransmission\u003c\/li\u003e\n\u003cli\u003eReceptor-blockade and ligand-competition studies\u003c\/li\u003e\n\u003cli\u003eGPCR pharmacology, ligand-binding, and signaling assays\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003eOverall, Nebivolol hydrochloride (R-65824) is appropriate when a defined chemical perturbant is needed to connect Adrenergic Receptors with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in cardiovascular and neuroscience models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"10 mg","offer_id":57805310198105,"sku":"S1549-10MG","price":77.0,"currency_code":"EUR","in_stock":true},{"title":"50 mg","offer_id":57805310230873,"sku":"S1549-50MG","price":167.0,"currency_code":"EUR","in_stock":true},{"title":"1 ml (10mM\/DMSO)","offer_id":57805310263641,"sku":"S1549-1ML\/DMSO","price":127.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/nebivolol-chemical-structure-s1549.gif?v=1776173718","url":"https:\/\/absource.de\/products\/nebivolol-hydrochloride-r-65824-s1549","provider":"Absource Diagnostics","version":"1.0","type":"link"}