{"product_id":"nedisertib-m3814-s8586","title":"Nedisertib (M3814)","description":"\u003cp\u003e\u003cstrong\u003eNedisertib (M3814)\u003c\/strong\u003e is an inhibitor of DNA-PK used in studies of DNA Damage Response. In practice, this places the compound in experiments that measure checkpoint activation, DNA repair, and genome-stability control in cancer, cell signaling, and dna damage \/ repair models.\u003c\/p\u003e\n\n\u003cp\u003eBy inhibiting DNA-PK, Nedisertib (M3814) can be used to examine checkpoint activation, DNA repair, and genome-stability control. The kinase annotation adds relevance to biochemical kinase assays, phospho-signaling studies, and selectivity profiling, together with downstream-response mapping in the same experimental setting. In cancer, cell signaling, and dna damage \/ repair models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.\u003c\/p\u003e\n\n\u003ch2\u003eResearch Applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eTarget-focused assays involving DNA-PK\u003c\/li\u003e\n\u003cli\u003ePathway perturbation studies connected to DNA Damage Response\u003c\/li\u003e\n\u003cli\u003eConcentration-response inhibition and target-dependence studies\u003c\/li\u003e\n\u003cli\u003eBiochemical kinase assays, phospho-signaling studies, and selectivity profiling\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003eOverall, Nedisertib (M3814) is appropriate when a defined chemical perturbant is needed to connect DNA-PK with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in cancer, cell signaling, and dna damage \/ repair models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"5 mg","offer_id":57809623679321,"sku":"S8586-5MG","price":254.0,"currency_code":"EUR","in_stock":true},{"title":"25 mg","offer_id":57809623712089,"sku":"S8586-25MG","price":763.0,"currency_code":"EUR","in_stock":true},{"title":"100 mg","offer_id":57809623744857,"sku":"S8586-100MG","price":1955.0,"currency_code":"EUR","in_stock":true},{"title":"1 g","offer_id":57809623777625,"sku":"S8586-1G","price":4884.0,"currency_code":"EUR","in_stock":true},{"title":"1 ml (10mM\/DMSO)","offer_id":57809623810393,"sku":"S8586-1ML\/DMSO","price":323.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/m3814-chemical-structure-s8586.gif?v=1776202998","url":"https:\/\/absource.de\/products\/nedisertib-m3814-s8586","provider":"Absource Diagnostics","version":"1.0","type":"link"}