{"product_id":"neuropeptide-y-p1122","title":"Neuropeptide Y","description":"\u003ch2\u003eAbout the Target\u003c\/h2\u003e\u003cp\u003eNeuropeptide Y (NPY), a 36 amino acid peptide widely distributed within central nervous system neurons, is a neuroprotective agent against β-amyloid neurotoxicity which influences the synthesis and the release of nerve growth factor (NGF) by cortical neurons. The mapped target for this entry is Neuropeptide Y receptor family (NPY1R, NPY2R, and NPY5R). This target context is most often investigated as part of ligand-responsive signaling, where receptor occupancy can reshape downstream second-messenger output, trafficking, secretion, excitability, or transcriptional programs. Researchers often use this biology in neurobiology studies, where pathway perturbation can shape neuronal activity, synaptic organization, glial responses, and neurodegenerative phenotypes. This framing is especially useful when investigators want to connect a controlled ligand stimulus with rapidly changing cellular phenotypes.\u003c\/p\u003e\u003ch2\u003eResearch Context\u003c\/h2\u003e\u003cp\u003eAs an agonist-format peptide, it is typically used to trigger pathway activation on demand and to compare acute signaling events with longer adaptive changes such as receptor desensitization or altered transcriptional output. In practice, dose-response design, timing, and matched control conditions are important for separating direct target engagement from delayed compensatory responses. Because more than one mapped molecular node is represented in the enrichment, pathway readouts should be interpreted with awareness that the phenotype may integrate multiple signaling inputs.\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003epair peptide treatment with pathway-proximal signaling or trafficking readouts whenever possible\u003c\/li\u003e\n\u003cli\u003ecompare responses across cell states or model systems with different receptor abundance\u003c\/li\u003e\n\u003cli\u003edistinguish primary target engagement from downstream adaptation during longer incubations\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eExperimental interpretation should therefore connect early pathway changes with later phenotypic outputs, rather than relying on a single endpoint in isolation.\u003c\/p\u003e\u003ch2\u003eFormat Considerations\u003c\/h2\u003e\u003cp\u003eUsing the regular format helps keep comparative experiments aligned, especially when the same signaling question is being tested across multiple models or readout platforms. In comparative workflows, consistency of preparation, exposure window, and matched controls is often as important as the nominal treatment itself. This is particularly helpful for comparative experiments, benchmark studies, and orthogonal validation in which small differences in formulation or handling can complicate interpretation. For peptide-centered workflows, conclusions are usually strongest when biological readouts are paired with consistent preparation and appropriately matched reference conditions.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"5 mg","offer_id":57636821533017,"sku":"P1122-5MG","price":265.0,"currency_code":"EUR","in_stock":true},{"title":"25 mg","offer_id":57636821565785,"sku":"P1122-25MG","price":795.0,"currency_code":"EUR","in_stock":true},{"title":"100 mg","offer_id":57636821598553,"sku":"P1122-100MG","price":1936.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/p1122-neuropeptide-y-human-chemical-structure.png?v=1774212360","url":"https:\/\/absource.de\/products\/neuropeptide-y-p1122","provider":"Absource Diagnostics","version":"1.0","type":"link"}