{"product_id":"ng2-cspg4-antibody-sc-f3010","title":"NG2\/CSPG4 Antibody","description":"\u003ch2\u003eAbout the Target\u003c\/h2\u003e\u003cp\u003eNG2\/CSPG4 (chondroitin sulfate proteoglycan 4) is a highly complex transmembrane proteoglycan with a large extracellular region divided into three domains (D1-D3), a transmembrane segment, and a short cytoplasmic tail containing signaling motifs. The ectodomain is primarily structured by β-sheet motifs and flexible loops, with the D1 domain most accessible for extracellular interactions, enabling NG2\/CSPG4 to function as a co-receptor that sequesters growth factors such as FGF-2 and presents them to receptors like FGFR-1, forming trimeric signaling complexes. Depending on the literature source, NG2\/CSPG4 may also be discussed as NG2\/CSPG4 and Chondroitin sulfate proteoglycan 4.\u003c\/p\u003e\u003cp\u003eReported cellular context includes cellmembrane and membrane, which can matter when signal is compared across treatments or changing cell states. Following NG2\/CSPG4 across matched perturbations can help separate abundance effects from shifts in localization, complex assembly, or pathway state.\u003c\/p\u003e\u003ch2\u003eResearch Context\u003c\/h2\u003e\u003cp\u003eNG2\/CSPG4 is commonly interpreted in the context of cancer, neuroscience, and cell signaling research, and readouts are often stronger when a study separates expression changes from compartment-level redistribution. When reported signal spans cellmembrane and membrane, a defined reference condition can make comparisons more interpretable across perturbations, passages, or replicate sets.\u003c\/p\u003e\u003cp\u003eConsider these angles when interpreting target-level changes:\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eapparent redistribution between cellmembrane and membrane across matched conditions\u003c\/li\u003e\n\u003cli\u003echanges associated with proliferative state, oncogenic signaling, or treatment response\u003c\/li\u003e\n\u003cli\u003ecompartment-specific patterns relevant to neuronal polarity, transport, or synaptic context\u003c\/li\u003e\n\u003cli\u003esignal-dependent shifts after ligand, inhibitor, or growth-factor perturbation\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eVariant Considerations\u003c\/h2\u003e\u003cp\u003eIf your project spans exploratory questions, the regular version offers a balanced option for establishing baseline signal behavior for NG2\/CSPG4. This can help when protocols evolve over time and the goal is to compare experiments using a stable reference workflow.\u003c\/p\u003e\u003cp\u003eStandardize sampling time, control choice, and downstream analysis thresholds so apparent differences in NG2\/CSPG4 reflect biology rather than handling. When interpreting NG2\/CSPG4, it is often useful to decide early whether the main question is overall abundance, compartmental enrichment, or context-dependent redistribution.\u003c\/p\u003e\u003cp\u003eFor multi-run studies, a shared reference condition can keep NG2\/CSPG4 trends easier to compare across datasets. That kind of consistency is especially helpful when follow-up work expands to new perturbations, model systems, or longitudinal collections.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"20 µl","offer_id":57577991569753,"sku":"F3010-20UL","price":169.0,"currency_code":"EUR","in_stock":true},{"title":"100 µl","offer_id":57577991602521,"sku":"F3010-100UL","price":399.0,"currency_code":"EUR","in_stock":true},{"title":"2 × 100 µl","offer_id":57577991635289,"sku":"F3010-2X100UL","price":599.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/F3010-IF.png?v=1773600884","url":"https:\/\/absource.de\/products\/ng2-cspg4-antibody-sc-f3010","provider":"Absource Diagnostics","version":"1.0","type":"link"}