{"product_id":"ngbr-antibody-sc-f2763","title":"NgBR Antibody","description":"\u003ch2\u003eAbout the Target\u003c\/h2\u003e\u003cp\u003eNgBR(Nogo-B receptor) is a type I transmembrane protein initially identified as a specific receptor for Nogo-B (reticulon-4b), with a key role in endothelial cell chemotaxis and angiogenesis. Structurally, NgBR contains an intrinsically unstructured ectodomain that can adopt defined conformations upon ligand binding and a C-terminal cytoplasmic domain essential for binding partners such as NPC2 and Ras. Depending on the literature source, NGBR may also be discussed as C6orf68 and NUS1.\u003c\/p\u003e\u003cp\u003eReported cellular context includes endoplasmic reticulum and membrane, which can matter when signal is compared across treatments or changing cell states. Following NGBR across matched perturbations can help separate abundance effects from shifts in localization, complex assembly, or pathway state.\u003c\/p\u003e\u003ch2\u003eResearch Context\u003c\/h2\u003e\u003cp\u003eNGBR is commonly interpreted in the context of cancer, cardiovascular, and metabolism research, and readouts are often stronger when a study separates expression changes from compartment-level redistribution. When reported signal spans endoplasmic reticulum and membrane, a defined reference condition can make comparisons more interpretable across perturbations, passages, or replicate sets.\u003c\/p\u003e\u003cp\u003eConsider these angles when interpreting target-level changes:\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eapparent redistribution between endoplasmic reticulum and membrane across matched conditions\u003c\/li\u003e\n\u003cli\u003echanges associated with proliferative state, oncogenic signaling, or treatment response\u003c\/li\u003e\n\u003cli\u003echanges linked to vascular, contractile, or hemodynamic cell-state cues\u003c\/li\u003e\n\u003cli\u003eresponses linked to nutrient status, mitochondrial state, or metabolic rewiring\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eVariant Considerations\u003c\/h2\u003e\u003cp\u003eIf your project spans exploratory questions, the regular version offers a balanced option for establishing baseline signal behavior for NGBR. This can help when protocols evolve over time and the goal is to compare experiments using a stable reference workflow.\u003c\/p\u003e\u003cp\u003eStandardize sampling time, control choice, and downstream analysis thresholds so apparent differences in NGBR reflect biology rather than handling. When interpreting NGBR, it is often useful to decide early whether the main question is overall abundance, compartmental enrichment, or context-dependent redistribution.\u003c\/p\u003e\u003cp\u003eFor multi-run studies, a shared reference condition can keep NGBR trends easier to compare across datasets. That kind of consistency is especially helpful when follow-up work expands to new perturbations, model systems, or longitudinal collections.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"20 µl","offer_id":57577970598233,"sku":"F2763-20UL","price":199.0,"currency_code":"EUR","in_stock":true},{"title":"100 µl","offer_id":57577970631001,"sku":"F2763-100UL","price":489.0,"currency_code":"EUR","in_stock":true},{"title":"2 × 100 µl","offer_id":57577970663769,"sku":"F2763-2X100UL","price":729.0,"currency_code":"EUR","in_stock":true}],"url":"https:\/\/absource.de\/products\/ngbr-antibody-sc-f2763","provider":"Absource Diagnostics","version":"1.0","type":"link"}