{"product_id":"nilotinib-hydrochloride-monohydrate-s4895","title":"Nilotinib hydrochloride monohydrate","description":"\u003cp\u003e\u003cstrong\u003eNilotinib hydrochloride monohydrate\u003c\/strong\u003e is an inhibitor of AMPK used in studies of PI3K-Akt-mTOR Signaling and Autophagy. It is especially relevant when investigators need a named chemical input and interpretable readouts connected to growth-factor signaling, survival control, and nutrient-sensing outputs and autophagic flux, lysosomal turnover, and stress adaptation in angiogenesis, autophagy, and cancer models.\u003c\/p\u003e\n\n\u003cp\u003eBy inhibiting AMPK, Nilotinib hydrochloride monohydrate can be used to examine growth-factor signaling, survival control, and nutrient-sensing outputs and autophagic flux, lysosomal turnover, and stress adaptation. The kinase annotation adds relevance to biochemical kinase assays, phospho-signaling studies, and selectivity profiling, together with downstream-response mapping in the same experimental setting. In angiogenesis, autophagy, and cancer models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.\u003c\/p\u003e\n\n\u003ch2\u003eResearch Applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eTarget-focused assays involving AMPK\u003c\/li\u003e\n\u003cli\u003ePathway perturbation studies connected to PI3K-Akt-mTOR Signaling and Autophagy\u003c\/li\u003e\n\u003cli\u003eConcentration-response inhibition and target-dependence studies\u003c\/li\u003e\n\u003cli\u003eBiochemical kinase assays, phospho-signaling studies, and selectivity profiling\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003eOverall, Nilotinib hydrochloride monohydrate is appropriate when a defined chemical perturbant is needed to connect AMPK with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in angiogenesis, autophagy, and cancer models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"25 mg","offer_id":57809129570649,"sku":"S4895-25MG","price":144.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/s4895-nilotinib-hydrochloride-monohydrate-chemical-structure.gif?v=1776197250","url":"https:\/\/absource.de\/products\/nilotinib-hydrochloride-monohydrate-s4895","provider":"Absource Diagnostics","version":"1.0","type":"link"}