{"product_id":"niraparib-mk-4827-s2741","title":"Niraparib (MK-4827)","description":"\u003cp\u003e\u003cstrong\u003eNiraparib (MK-4827)\u003c\/strong\u003e is an inhibitor of PARP1 and PARP2 used in studies of DNA Damage Response and Apoptosis. It is especially relevant in apoptosis, cancer, and dna damage \/ repair models, where defined compound exposure can be linked to checkpoint activation, DNA repair, and genome-stability control and caspase-associated cell-death signaling and survival decisions.\u003c\/p\u003e\n\n\u003cp\u003eBy inhibiting PARP1 and PARP2, Niraparib (MK-4827) can be used to examine checkpoint activation, DNA repair, and genome-stability control and caspase-associated cell-death signaling and survival decisions. The enzyme annotation adds relevance to enzyme-activity assays, substrate-conversion studies, and mechanism profiling, together with downstream-response mapping in the same experimental setting. In apoptosis, cancer, and dna damage \/ repair models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.\u003c\/p\u003e\n\n\u003ch2\u003eResearch Applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eTarget-focused assays involving PARP1 and PARP2\u003c\/li\u003e\n\u003cli\u003ePathway perturbation studies connected to DNA Damage Response and Apoptosis\u003c\/li\u003e\n\u003cli\u003eConcentration-response inhibition and target-dependence studies\u003c\/li\u003e\n\u003cli\u003eEnzyme-activity assays, substrate-conversion studies, and mechanism profiling\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003eOverall, Niraparib (MK-4827) is appropriate when a defined chemical perturbant is needed to connect PARP1 and PARP2 with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in apoptosis, cancer, and dna damage \/ repair models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"5 mg","offer_id":57805709705561,"sku":"S2741-5MG","price":167.0,"currency_code":"EUR","in_stock":true},{"title":"50 mg","offer_id":57805709738329,"sku":"S2741-50MG","price":567.0,"currency_code":"EUR","in_stock":true},{"title":"200 mg","offer_id":57805709771097,"sku":"S2741-200MG","price":953.0,"currency_code":"EUR","in_stock":true},{"title":"1 g","offer_id":57805709803865,"sku":"S2741-1G","price":1936.0,"currency_code":"EUR","in_stock":true},{"title":"1 ml (10mM\/DMSO)","offer_id":57805709836633,"sku":"S2741-1ML\/DMSO","price":272.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/MK-4827-chemical-structure-s2741.gif?v=1776175602","url":"https:\/\/absource.de\/products\/niraparib-mk-4827-s2741","provider":"Absource Diagnostics","version":"1.0","type":"link"}