{"product_id":"niraparib-tosylate-s7625","title":"Niraparib tosylate","description":"\u003cp\u003e\u003cstrong\u003eNiraparib tosylate\u003c\/strong\u003e is an inhibitor of PARP1 and PARP2 used in studies of DNA Damage Response and Apoptosis. In practice, this places the compound in experiments that measure checkpoint activation, DNA repair, and genome-stability control and caspase-associated cell-death signaling and survival decisions in apoptosis, cancer, and dna damage \/ repair models.\u003c\/p\u003e\n\n\u003cp\u003eBy inhibiting PARP1 and PARP2, Niraparib tosylate can be used to examine checkpoint activation, DNA repair, and genome-stability control and caspase-associated cell-death signaling and survival decisions. The enzyme annotation adds relevance to enzyme-activity assays, substrate-conversion studies, and mechanism profiling, together with downstream-response mapping in the same experimental setting. In apoptosis, cancer, and dna damage \/ repair models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.\u003c\/p\u003e\n\n\u003ch2\u003eResearch Applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eTarget-focused assays involving PARP1 and PARP2\u003c\/li\u003e\n\u003cli\u003ePathway perturbation studies connected to DNA Damage Response and Apoptosis\u003c\/li\u003e\n\u003cli\u003eConcentration-response inhibition and target-dependence studies\u003c\/li\u003e\n\u003cli\u003eEnzyme-activity assays, substrate-conversion studies, and mechanism profiling\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003eOverall, Niraparib tosylate is appropriate when a defined chemical perturbant is needed to connect PARP1 and PARP2 with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in apoptosis, cancer, and dna damage \/ repair models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"5 mg","offer_id":57809502044505,"sku":"S7625-5MG","price":144.0,"currency_code":"EUR","in_stock":true},{"title":"25 mg","offer_id":57809502077273,"sku":"S7625-25MG","price":390.0,"currency_code":"EUR","in_stock":true},{"title":"100 mg","offer_id":57809502110041,"sku":"S7625-100MG","price":979.0,"currency_code":"EUR","in_stock":true},{"title":"1 g","offer_id":57809502142809,"sku":"S7625-1G","price":1444.0,"currency_code":"EUR","in_stock":true},{"title":"1 ml (10mM\/DMSO)","offer_id":57809502175577,"sku":"S7625-1ML\/DMSO","price":193.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/mk-4827-niraparib-tosylate-chemical-structure-s7625.gif?v=1776201635","url":"https:\/\/absource.de\/products\/niraparib-tosylate-s7625","provider":"Absource Diagnostics","version":"1.0","type":"link"}