{"product_id":"nmt55-p54nrb-antibody-sc-f3856","title":"nmt55\/p54nrb Antibody","description":"\u003ch2\u003eAbout the Target\u003c\/h2\u003e\u003cp\u003eNMT55\/p54nrb, also known as NONO (Non-POU domain-containing octamer-binding protein), is a multifunctional nuclear DNA- and RNA-binding protein playing essential roles in transcription regulation, pre-mRNA splicing, RNA retention, DNA repair, and chromatin remodeling. As a member of the DBHS (Drosophila behavior\/human splicing) protein family, NONO contains two RNA recognition motifs (RRMs) that facilitate interactions with RNA and protein partners, alongside coiled-coil domains enabling dimerization with related proteins SFPQ and PSPC1. Depending on the literature source, nmt55\/p54nrb may also be discussed as nmt55\/p54nrb and NRB54.\u003c\/p\u003e\u003cp\u003eReported cellular context includes chromosome and nucleus, which can matter when signal is compared across treatments or changing cell states. Following nmt55\/p54nrb across matched perturbations can help separate abundance effects from shifts in localization, complex assembly, or pathway state.\u003c\/p\u003e\u003ch2\u003eResearch Context\u003c\/h2\u003e\u003cp\u003enmt55\/p54nrb is commonly interpreted in the context of cancer and epigenetics research, and readouts are often stronger when a study separates expression changes from compartment-level redistribution. When reported signal spans chromosome and nucleus, a defined reference condition can make comparisons more interpretable across perturbations, passages, or replicate sets.\u003c\/p\u003e\u003cp\u003eConsider these angles when interpreting target-level changes:\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eapparent redistribution between chromosome and nucleus across matched conditions\u003c\/li\u003e\n\u003cli\u003echanges associated with proliferative state, oncogenic signaling, or treatment response\u003c\/li\u003e\n\u003cli\u003elinks between target behavior and transcriptional or chromatin-state changes\u003c\/li\u003e\n\u003cli\u003eco-patterning with orthogonal markers and control conditions that clarify pathway state\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eVariant Considerations\u003c\/h2\u003e\u003cp\u003eIf your project spans exploratory questions, the regular version offers a balanced option for establishing baseline signal behavior for nmt55\/p54nrb. This can help when protocols evolve over time and the goal is to compare experiments using a stable reference workflow.\u003c\/p\u003e\u003cp\u003eStandardize sampling time, control choice, and downstream analysis thresholds so apparent differences in nmt55\/p54nrb reflect biology rather than handling. When interpreting nmt55\/p54nrb, it is often useful to decide early whether the main question is overall abundance, compartmental enrichment, or context-dependent redistribution.\u003c\/p\u003e\u003cp\u003eFor multi-run studies, a shared reference condition can keep nmt55\/p54nrb trends easier to compare across datasets. That kind of consistency is especially helpful when follow-up work expands to new perturbations, model systems, or longitudinal collections.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"20 µl","offer_id":57578049896793,"sku":"F3856-20UL","price":199.0,"currency_code":"EUR","in_stock":true},{"title":"100 µl","offer_id":57578049929561,"sku":"F3856-100UL","price":489.0,"currency_code":"EUR","in_stock":true},{"title":"2 × 100 µl","offer_id":57578049962329,"sku":"F3856-2X100UL","price":729.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/F3856-IF.png?v=1773601527","url":"https:\/\/absource.de\/products\/nmt55-p54nrb-antibody-sc-f3856","provider":"Absource Diagnostics","version":"1.0","type":"link"}