{"product_id":"nos3-antibody-sc-f0354","title":"Phospho-eNOS (Ser1177) Antibody","description":"\u003ch2\u003eAbout the Target\u003c\/h2\u003e\u003cp\u003eEndothelial nitric oxide synthase (eNOS) is crucial for the regulation and maintenance of a healthy cardiovascular system. The significance of eNOS is highlighted by genetic polymorphisms in the eNOS gene, disruption of eNOS dimerization, and its complex signaling regulation. eNOS is encoded by the NOS3 gene, located in the 7q35-7q36 region of chromosome 7 in humans. Depending on the literature source, NOS3 may also be discussed as Phospho-eNOS (Ser1177) and eNOS (phospho S1177).\u003c\/p\u003e\u003cp\u003eReported cellular context includes cell membrane, cytoplasm, cytoskeleton, and golgi apparatus, which can matter when signal is compared across treatments or changing cell states. Following NOS3 across matched perturbations can help separate abundance effects from shifts in localization, complex assembly, or pathway state.\u003c\/p\u003e\u003ch2\u003eResearch Context\u003c\/h2\u003e\u003cp\u003eNOS3 is commonly interpreted in the context of cardiovascular and cell signaling research, and readouts are often stronger when a study separates expression changes from compartment-level redistribution. When reported signal spans cell membrane, cytoplasm, and cytoskeleton, a defined reference condition can make comparisons more interpretable across perturbations, passages, or replicate sets.\u003c\/p\u003e\u003cp\u003eConsider these angles when interpreting target-level changes:\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eapparent redistribution between cell membrane, cytoplasm, and cytoskeleton across matched conditions\u003c\/li\u003e\n\u003cli\u003echanges linked to vascular, contractile, or hemodynamic cell-state cues\u003c\/li\u003e\n\u003cli\u003esignal-dependent shifts after ligand, inhibitor, or growth-factor perturbation\u003c\/li\u003e\n\u003cli\u003edifferences between total target abundance and site-specific regulation when modified forms are compared\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eVariant Considerations\u003c\/h2\u003e\u003cp\u003eIf your project spans exploratory questions, the regular version offers a balanced option for establishing baseline signal behavior for NOS3. This can help when protocols evolve over time and the goal is to compare experiments using a stable reference workflow.\u003c\/p\u003e\u003cp\u003eStandardize sampling time, control choice, and downstream analysis thresholds so apparent differences in NOS3 reflect biology rather than handling. When interpreting NOS3, it is often useful to decide early whether the main question is overall abundance, compartmental enrichment, or context-dependent redistribution.\u003c\/p\u003e\u003cp\u003eFor multi-run studies, a shared reference condition can keep NOS3 trends easier to compare across datasets. That kind of consistency is especially helpful when follow-up work expands to new perturbations, model systems, or longitudinal collections.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"20 µl","offer_id":57577445785945,"sku":"F0354-20UL","price":169.0,"currency_code":"EUR","in_stock":true},{"title":"100 µl","offer_id":57577445818713,"sku":"F0354-100UL","price":389.0,"currency_code":"EUR","in_stock":true},{"title":"2 × 100 µl","offer_id":57577445851481,"sku":"F0354-2X100UL","price":579.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/F0354-wb.gif?v=1773598368","url":"https:\/\/absource.de\/products\/nos3-antibody-sc-f0354","provider":"Absource Diagnostics","version":"1.0","type":"link"}