{"product_id":"npm1-antibody-sc-f1908","title":"NPM1 Antibody","description":"\u003ch2\u003eAbout the Target\u003c\/h2\u003e\u003cp\u003eNucleophosmin (NPM1), B23, is an abundant nucleolar protein involved in multiple cellular processes such as ribosome biogenesis, mRNA processing, chromatin remodeling, and maintaining genomic stability. NPM1 is involved in DNA repair processes, including homologous recombination (HR) and base excision repair (BER). It gets phosphorylated and directed to sites of DNA damage, where it interacts with repair proteins like γH2AX and BRCA1 to aid in fixing double-strand breaks. Depending on the literature source, NPM1 may also be discussed as Numatrin and NO38.\u003c\/p\u003e\u003cp\u003eReported cellular context includes cytoplasm, cytoskeleton, and nucleus, which can matter when signal is compared across treatments or changing cell states. Following NPM1 across matched perturbations can help separate abundance effects from shifts in localization, complex assembly, or pathway state. In practice, this target is often considered at the family or isoform-group level, so experimental interpretation benefits from matched controls and clear comparison logic.\u003c\/p\u003e\u003ch2\u003eResearch Context\u003c\/h2\u003e\u003cp\u003eNPM1 is commonly interpreted in the context of cancer, dna damage \/ repair, and epigenetics research, and readouts are often stronger when a study separates expression changes from compartment-level redistribution. When reported signal spans cytoplasm, cytoskeleton, and nucleus, a defined reference condition can make comparisons more interpretable across perturbations, passages, or replicate sets.\u003c\/p\u003e\u003cp\u003eConsider these angles when interpreting target-level changes:\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eapparent redistribution between cytoplasm, cytoskeleton, and nucleus across matched conditions\u003c\/li\u003e\n\u003cli\u003echanges associated with proliferative state, oncogenic signaling, or treatment response\u003c\/li\u003e\n\u003cli\u003estress-induced changes after checkpoint activation or genotoxic challenge\u003c\/li\u003e\n\u003cli\u003elinks between target behavior and transcriptional or chromatin-state changes\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eVariant Considerations\u003c\/h2\u003e\u003cp\u003eIf your project spans exploratory questions, the regular version offers a balanced option for establishing baseline signal behavior for NPM1. This can help when protocols evolve over time and the goal is to compare experiments using a stable reference workflow.\u003c\/p\u003e\u003cp\u003eStandardize sampling time, control choice, and downstream analysis thresholds so apparent differences in NPM1 reflect biology rather than handling. When interpreting NPM1, it is often useful to decide early whether the main question is overall abundance, compartmental enrichment, or context-dependent redistribution.\u003c\/p\u003e\u003cp\u003eFor multi-run studies, a shared reference condition can keep NPM1 trends easier to compare across datasets. That kind of consistency is especially helpful when follow-up work expands to new perturbations, model systems, or longitudinal collections.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"20 µl","offer_id":57577831989593,"sku":"F1908-20UL","price":179.0,"currency_code":"EUR","in_stock":true},{"title":"100 µl","offer_id":57577832022361,"sku":"F1908-100UL","price":399.0,"currency_code":"EUR","in_stock":true},{"title":"2 × 100 µl","offer_id":57577832055129,"sku":"F1908-2X100UL","price":599.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/F1908-IHC1.jpg?v=1773600076","url":"https:\/\/absource.de\/products\/npm1-antibody-sc-f1908","provider":"Absource Diagnostics","version":"1.0","type":"link"}