{"product_id":"nr1c1-antibody-sc-f4266","title":"PPARα Antibody","description":"\u003ch2\u003eAbout the Target\u003c\/h2\u003e\u003cp\u003ePeroxisome Proliferator-Activated Receptor Alpha (PPARα) is a ligand-activated nuclear receptor and transcription factor, classified within the nuclear receptor superfamily as NR1C1 of the NR1C subfamily. PPARα is predominantly expressed in metabolically active tissues such as the liver, skeletal muscle, heart, and brown adipose tissue. It exhibits the modular domain structure typical of nuclear receptors, including an N-terminal A\/B domain harboring a ligand-independent activation function (AF-1), a highly conserved DNA-binding domain (DBD) with two zinc finger motifs that recognize specific peroxisome proliferator response elements (PPREs) in target gene promoters, a hinge region, and a C-terminal ligand-binding. Depending on the literature source, NR1C1 may also be discussed as PPARalpha and Peroxisome proliferator-activated receptor alpha; PPAR-alpha; Nuclear receptor subfamily 1 group C member 1; PPARA; NR1C1; PPAR.\u003c\/p\u003e\u003cp\u003eReported cellular context includes nucleus, which can matter when signal is compared across treatments or changing cell states. Following NR1C1 across matched perturbations can help separate abundance effects from shifts in localization, complex assembly, or pathway state.\u003c\/p\u003e\u003ch2\u003eResearch Context\u003c\/h2\u003e\u003cp\u003eNR1C1 is commonly interpreted in the context of cardiovascular, metabolism, and cell signaling research, and readouts are often stronger when a study separates expression changes from compartment-level redistribution. When reported signal spans nucleus, a defined reference condition can make comparisons more interpretable across perturbations, passages, or replicate sets.\u003c\/p\u003e\u003cp\u003eConsider these angles when interpreting target-level changes:\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003esignal enrichment within nucleus relative to the broader cellular background\u003c\/li\u003e\n\u003cli\u003echanges linked to vascular, contractile, or hemodynamic cell-state cues\u003c\/li\u003e\n\u003cli\u003eresponses linked to nutrient status, mitochondrial state, or metabolic rewiring\u003c\/li\u003e\n\u003cli\u003esignal-dependent shifts after ligand, inhibitor, or growth-factor perturbation\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eVariant Considerations\u003c\/h2\u003e\u003cp\u003eIf your project spans exploratory questions, the regular version offers a balanced option for establishing baseline signal behavior for NR1C1. This can help when protocols evolve over time and the goal is to compare experiments using a stable reference workflow.\u003c\/p\u003e\u003cp\u003eStandardize sampling time, control choice, and downstream analysis thresholds so apparent differences in NR1C1 reflect biology rather than handling. When interpreting NR1C1, it is often useful to decide early whether the main question is overall abundance, compartmental enrichment, or context-dependent redistribution.\u003c\/p\u003e\u003cp\u003eFor multi-run studies, a shared reference condition can keep NR1C1 trends easier to compare across datasets. That kind of consistency is especially helpful when follow-up work expands to new perturbations, model systems, or longitudinal collections.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"20 µl","offer_id":57578066706777,"sku":"F4266-20UL","price":199.0,"currency_code":"EUR","in_stock":true},{"title":"100 µl","offer_id":57578066739545,"sku":"F4266-100UL","price":489.0,"currency_code":"EUR","in_stock":true},{"title":"2 × 100 µl","offer_id":57578066772313,"sku":"F4266-2X100UL","price":729.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/F4266-IF.png?v=1773601670","url":"https:\/\/absource.de\/products\/nr1c1-antibody-sc-f4266","provider":"Absource Diagnostics","version":"1.0","type":"link"}