{"product_id":"nrd167-s9903","title":"NRD167","description":"\u003cp\u003e\u003cstrong\u003eNRD167\u003c\/strong\u003e is an inhibitor of Sirtuins used in studies of DNA Damage Response and Epigenetic Regulation. In practice, this places the compound in experiments that measure checkpoint activation, DNA repair, and genome-stability control and chromatin-state control, histone modification, and transcriptional regulation in aging, cancer, and dna damage \/ repair models.\u003c\/p\u003e\n\n\u003cp\u003eBy inhibiting Sirtuins, NRD167 can be used to examine checkpoint activation, DNA repair, and genome-stability control and chromatin-state control, histone modification, and transcriptional regulation. The epigenetic regulator annotation adds relevance to chromatin, epigenetic, and gene-expression profiling, together with downstream-response mapping in the same experimental setting. In aging, cancer, and dna damage \/ repair models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.\u003c\/p\u003e\n\n\u003ch2\u003eResearch Applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eTarget-focused assays involving Sirtuins\u003c\/li\u003e\n\u003cli\u003ePathway perturbation studies connected to DNA Damage Response and Epigenetic Regulation\u003c\/li\u003e\n\u003cli\u003eConcentration-response inhibition and target-dependence studies\u003c\/li\u003e\n\u003cli\u003eChromatin, epigenetic, and gene-expression profiling\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003eOverall, NRD167 is appropriate when a defined chemical perturbant is needed to connect Sirtuins with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in aging, cancer, and dna damage \/ repair models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"5 mg","offer_id":57809757143385,"sku":"S9903-5MG","price":183.0,"currency_code":"EUR","in_stock":true},{"title":"25 mg","offer_id":57809757176153,"sku":"S9903-25MG","price":557.0,"currency_code":"EUR","in_stock":true},{"title":"100 mg","offer_id":57809757208921,"sku":"S9903-100MG","price":1382.0,"currency_code":"EUR","in_stock":true},{"title":"1 ml (10mM\/DMSO)","offer_id":57809757241689,"sku":"S9903-1ML\/DMSO","price":242.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/s9903-nrd167-chemical-structure.gif?v=1776205264","url":"https:\/\/absource.de\/products\/nrd167-s9903","provider":"Absource Diagnostics","version":"1.0","type":"link"}