{"product_id":"nutlin-3a-s8059","title":"Nutlin-3a","description":"\u003cp\u003e\u003cstrong\u003eNutlin-3a\u003c\/strong\u003e is an inhibitor of MDM2 and MDMX and related targets used in studies of Apoptosis and Autophagy. In practice, this places the compound in experiments that measure caspase-associated cell-death signaling and survival decisions and autophagic flux, lysosomal turnover, and stress adaptation in apoptosis, autophagy, and cancer models.\u003c\/p\u003e\n\n\u003cp\u003eBy inhibiting MDM2 and MDMX and related targets, Nutlin-3a can be used to examine caspase-associated cell-death signaling and survival decisions and autophagic flux, lysosomal turnover, and stress adaptation. This context is compatible with apoptosis, viability, and caspase-readout assays and autophagy-flux, lysosome, and cargo-clearance assays, as well as transcriptional, biochemical, or phenotypic comparisons linked to the annotated pathway state. In apoptosis, autophagy, and cancer models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.\u003c\/p\u003e\n\n\u003ch2\u003eResearch Applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eTarget-focused assays involving MDM2 and MDMX and related targets\u003c\/li\u003e\n\u003cli\u003ePathway perturbation studies connected to Apoptosis and Autophagy\u003c\/li\u003e\n\u003cli\u003eConcentration-response inhibition and target-dependence studies\u003c\/li\u003e\n\u003cli\u003ePhenotypic profiling in apoptosis, autophagy, and cancer models\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003eOverall, Nutlin-3a is appropriate when a defined chemical perturbant is needed to connect MDM2 and MDMX and related targets with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in apoptosis, autophagy, and cancer models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"5 mg","offer_id":57809575117145,"sku":"S8059-5MG","price":193.0,"currency_code":"EUR","in_stock":true},{"title":"25 mg","offer_id":57809575149913,"sku":"S8059-25MG","price":579.0,"currency_code":"EUR","in_stock":true},{"title":"100 mg","offer_id":57809575182681,"sku":"S8059-100MG","price":1444.0,"currency_code":"EUR","in_stock":true},{"title":"1 ml (10mM\/DMSO)","offer_id":57809575215449,"sku":"S8059-1ML\/DMSO","price":232.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/Nutlin-3a-chemical-structure-s8059.gif?v=1776202273","url":"https:\/\/absource.de\/products\/nutlin-3a-s8059","provider":"Absource Diagnostics","version":"1.0","type":"link"}