{"product_id":"nvp-aew541-s1034","title":"NVP-AEW541","description":"\u003cp\u003e\u003cstrong\u003eNVP-AEW541\u003c\/strong\u003e is an inhibitor of IGF-1R used in studies of PI3K-Akt-mTOR Signaling. In practice, this places the compound in experiments that measure growth-factor signaling, survival control, and nutrient-sensing outputs in cancer, cell signaling, and metabolism models.\u003c\/p\u003e\n\n\u003cp\u003eBy inhibiting IGF-1R, NVP-AEW541 can be used to examine growth-factor signaling, survival control, and nutrient-sensing outputs. The kinase annotation adds relevance to biochemical kinase assays, phospho-signaling studies, and selectivity profiling, together with downstream-response mapping in the same experimental setting. In cancer, cell signaling, and metabolism models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.\u003c\/p\u003e\n\n\u003ch2\u003eResearch Applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eTarget-focused assays involving IGF-1R\u003c\/li\u003e\n\u003cli\u003ePathway perturbation studies connected to PI3K-Akt-mTOR Signaling\u003c\/li\u003e\n\u003cli\u003eConcentration-response inhibition and target-dependence studies\u003c\/li\u003e\n\u003cli\u003eBiochemical kinase assays, phospho-signaling studies, and selectivity profiling\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003eOverall, NVP-AEW541 is appropriate when a defined chemical perturbant is needed to connect IGF-1R with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in cancer, cell signaling, and metabolism models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"2 mg","offer_id":57805178863961,"sku":"S1034-2MG","price":105.0,"currency_code":"EUR","in_stock":true},{"title":"5 mg","offer_id":57805178896729,"sku":"S1034-5MG","price":186.0,"currency_code":"EUR","in_stock":true},{"title":"10 mg","offer_id":57805178929497,"sku":"S1034-10MG","price":291.0,"currency_code":"EUR","in_stock":true},{"title":"1 ml (10mM\/DMSO)","offer_id":57805178962265,"sku":"S1034-1ML\/DMSO","price":225.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/NVP-AEW541-chemical-structure-S1034.gif?v=1776172776","url":"https:\/\/absource.de\/products\/nvp-aew541-s1034","provider":"Absource Diagnostics","version":"1.0","type":"link"}