{"product_id":"obeticholic-acid-int-747-s7660","title":"Obeticholic Acid (INT-747)","description":"\u003cp\u003e\u003cstrong\u003eObeticholic Acid (INT-747)\u003c\/strong\u003e is an agonist of FXR used in studies of Autophagy and Hormone Signaling and related signaling programs. It is especially relevant in autophagy, endocrinology, and metabolism models, where defined compound exposure can be linked to autophagic flux, lysosomal turnover, and stress adaptation and ligand-dependent transcriptional programs and endocrine regulation.\u003c\/p\u003e\n\n\u003cp\u003eBy activating FXR, Obeticholic Acid (INT-747) can be used to examine autophagic flux, lysosomal turnover, and stress adaptation and ligand-dependent transcriptional programs and endocrine regulation. The nuclear receptor annotation adds relevance to reporter-gene, receptor-binding, and transcriptional assays, together with downstream-response mapping in the same experimental setting. In autophagy, endocrinology, and metabolism models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.\u003c\/p\u003e\n\n\u003ch2\u003eResearch Applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eTarget-focused assays involving FXR\u003c\/li\u003e\n\u003cli\u003ePathway perturbation studies connected to Autophagy and Hormone Signaling and related signaling programs\u003c\/li\u003e\n\u003cli\u003eAgonist-response and downstream signaling studies\u003c\/li\u003e\n\u003cli\u003eReporter-gene, receptor-binding, and transcriptional assays\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003eOverall, Obeticholic Acid (INT-747) is appropriate when a defined chemical perturbant is needed to connect FXR with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in autophagy, endocrinology, and metabolism models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"5 mg","offer_id":57809528914265,"sku":"S7660-5MG","price":144.0,"currency_code":"EUR","in_stock":true},{"title":"25 mg","offer_id":57809528947033,"sku":"S7660-25MG","price":390.0,"currency_code":"EUR","in_stock":true},{"title":"100 mg","offer_id":57809528979801,"sku":"S7660-100MG","price":960.0,"currency_code":"EUR","in_stock":true},{"title":"1 g","offer_id":57809529012569,"sku":"S7660-1G","price":1936.0,"currency_code":"EUR","in_stock":true},{"title":"1 ml (10mM\/DMSO)","offer_id":57809529045337,"sku":"S7660-1ML\/DMSO","price":193.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/obeticholic-acid-chemical-structure-s7660.gif?v=1776201683","url":"https:\/\/absource.de\/products\/obeticholic-acid-int-747-s7660","provider":"Absource Diagnostics","version":"1.0","type":"link"}