{"product_id":"on123300-s8161","title":"ON123300","description":"\u003cp\u003e\u003cstrong\u003eON123300\u003c\/strong\u003e is an inhibitor of CDK and RET and related targets used in studies of MAPK \/ ERK Signaling and Cell Cycle Regulation. It is especially relevant in cancer, cell cycle, and cell signaling models, where defined compound exposure can be linked to mitogenic kinase cascades, proliferation control, and differentiation-linked signaling and checkpoint control, mitotic progression, and proliferation timing.\u003c\/p\u003e\n\n\u003cp\u003eBy inhibiting CDK and RET and related targets, ON123300 can be used to examine mitogenic kinase cascades, proliferation control, and differentiation-linked signaling and checkpoint control, mitotic progression, and proliferation timing. The kinase annotation adds relevance to biochemical kinase assays, phospho-signaling studies, and selectivity profiling, together with downstream-response mapping in the same experimental setting. In cancer, cell cycle, and cell signaling models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.\u003c\/p\u003e\n\n\u003ch2\u003eResearch Applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eTarget-focused assays involving CDK and RET and related targets\u003c\/li\u003e\n\u003cli\u003ePathway perturbation studies connected to MAPK \/ ERK Signaling and Cell Cycle Regulation\u003c\/li\u003e\n\u003cli\u003eConcentration-response inhibition and target-dependence studies\u003c\/li\u003e\n\u003cli\u003eBiochemical kinase assays, phospho-signaling studies, and selectivity profiling\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003eOverall, ON123300 is appropriate when a defined chemical perturbant is needed to connect CDK and RET and related targets with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in cancer, cell cycle, and cell signaling models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"5 mg","offer_id":57809584652633,"sku":"S8161-5MG","price":144.0,"currency_code":"EUR","in_stock":true},{"title":"25 mg","offer_id":57809584685401,"sku":"S8161-25MG","price":439.0,"currency_code":"EUR","in_stock":true},{"title":"100 mg","offer_id":57809584718169,"sku":"S8161-100MG","price":953.0,"currency_code":"EUR","in_stock":true},{"title":"1 g","offer_id":57809584750937,"sku":"S8161-1G","price":2938.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/on123300-chemical-structure-s8161.gif?v=1776202388","url":"https:\/\/absource.de\/products\/on123300-s8161","provider":"Absource Diagnostics","version":"1.0","type":"link"}