{"product_id":"ontunisertib-e6661","title":"Ontunisertib","description":"\u003cp\u003e\u003cstrong\u003eOntunisertib\u003c\/strong\u003e is an inhibitor of ALK used in studies of MAPK \/ ERK Signaling and TGF-beta \/ Smad Signaling. It is especially relevant when investigators need a named chemical input and interpretable readouts connected to mitogenic kinase cascades, proliferation control, and differentiation-linked signaling and Smad-mediated transcription, differentiation, and fibrotic signaling in cancer, cell signaling, and developmental biology models.\u003c\/p\u003e\n\n\u003cp\u003eBy inhibiting ALK, Ontunisertib can be used to examine mitogenic kinase cascades, proliferation control, and differentiation-linked signaling and Smad-mediated transcription, differentiation, and fibrotic signaling. The kinase annotation adds relevance to biochemical kinase assays, phospho-signaling studies, and selectivity profiling, together with downstream-response mapping in the same experimental setting. In cancer, cell signaling, and developmental biology models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.\u003c\/p\u003e\n\n\u003ch2\u003eResearch Applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eTarget-focused assays involving ALK\u003c\/li\u003e\n\u003cli\u003ePathway perturbation studies connected to MAPK \/ ERK Signaling and TGF-beta \/ Smad Signaling\u003c\/li\u003e\n\u003cli\u003eConcentration-response inhibition and target-dependence studies\u003c\/li\u003e\n\u003cli\u003eBiochemical kinase assays, phospho-signaling studies, and selectivity profiling\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003eOverall, Ontunisertib is appropriate when a defined chemical perturbant is needed to connect ALK with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in cancer, cell signaling, and developmental biology models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"5 mg","offer_id":57805033406809,"sku":"E6661-5MG","price":194.0,"currency_code":"EUR","in_stock":true},{"title":"25 mg","offer_id":57805033439577,"sku":"E6661-25MG","price":488.0,"currency_code":"EUR","in_stock":true},{"title":"100 mg","offer_id":57805033472345,"sku":"E6661-100MG","price":953.0,"currency_code":"EUR","in_stock":true},{"title":"1 g","offer_id":57805033505113,"sku":"E6661-1G","price":2919.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/E6661-Ontunisertib-chemical-structure.png?v=1776170966","url":"https:\/\/absource.de\/products\/ontunisertib-e6661","provider":"Absource Diagnostics","version":"1.0","type":"link"}