{"product_id":"os9-antibody-sc-f1005","title":"OS9 Antibody","description":"\u003ch2\u003eAbout the Target\u003c\/h2\u003e\u003cp\u003eOS9 is an ER-resident glycoprotein containing a mannose-6-phosphate receptor homology domain, which is also found in yeast and mammalian lectins involved in endoplasmic reticulum-associated degradation (ERAD). OS9 fused to the C-terminal domain of YOS9 can complement the ERAD defect in yeast Δyos9 mutants. OS9 deficiency results in activation of the unfolded protein response and reduces salt tolerance, highlighting its role during ER stress.\u003c\/p\u003e\u003cp\u003eReported cellular context includes endoplasmic reticulum, which can matter when signal is compared across treatments or changing cell states. Following OS9 across matched perturbations can help separate abundance effects from shifts in localization, complex assembly, or pathway state.\u003c\/p\u003e\u003ch2\u003eResearch Context\u003c\/h2\u003e\u003cp\u003eOS9 is commonly interpreted in the context of immunology research, and readouts are often stronger when a study separates expression changes from compartment-level redistribution. When reported signal spans endoplasmic reticulum, a defined reference condition can make comparisons more interpretable across perturbations, passages, or replicate sets.\u003c\/p\u003e\u003cp\u003eConsider these angles when interpreting target-level changes:\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003esignal enrichment within endoplasmic reticulum relative to the broader cellular background\u003c\/li\u003e\n\u003cli\u003econtext differences tied to immune-cell state, activation, or lineage composition\u003c\/li\u003e\n\u003cli\u003eco-patterning with orthogonal markers and control conditions that clarify pathway state\u003c\/li\u003e\n\u003cli\u003etime-matched comparisons so changes reflect biology rather than handling or sampling drift\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eVariant Considerations\u003c\/h2\u003e\u003cp\u003eIf your project spans exploratory questions, the regular version offers a balanced option for establishing baseline signal behavior for OS9. This can help when protocols evolve over time and the goal is to compare experiments using a stable reference workflow.\u003c\/p\u003e\u003cp\u003eStandardize sampling time, control choice, and downstream analysis thresholds so apparent differences in OS9 reflect biology rather than handling. When interpreting OS9, it is often useful to decide early whether the main question is overall abundance, compartmental enrichment, or context-dependent redistribution.\u003c\/p\u003e\u003cp\u003eFor multi-run studies, a shared reference condition can keep OS9 trends easier to compare across datasets. That kind of consistency is especially helpful when follow-up work expands to new perturbations, model systems, or longitudinal collections.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"20 µl","offer_id":57577587966297,"sku":"F1005-20UL","price":149.0,"currency_code":"EUR","in_stock":true},{"title":"100 µl","offer_id":57577587999065,"sku":"F1005-100UL","price":329.0,"currency_code":"EUR","in_stock":true},{"title":"2 × 100 µl","offer_id":57577588031833,"sku":"F1005-2X100UL","price":489.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/F1005-IHC1.jpg?v=1773599182","url":"https:\/\/absource.de\/products\/os9-antibody-sc-f1005","provider":"Absource Diagnostics","version":"1.0","type":"link"}