{"product_id":"p-glycoprotein-mdr1-or-abcb1-or-cd243-antibody-western-blot-validated","title":"P-glycoprotein (MDR1 or ABCB1 or CD243) Antibody - Western Blot Validated","description":"\u003ch2\u003eProtein Function\u003c\/h2\u003e\n\u003cp\u003eThis antibody helps you examine P-glycoprotein while keeping condition-to-condition contrasts straightforward. P-glycoprotein is a contact-site protein that shapes barrier properties and signaling at the cell surface. For comparison-heavy studies, consistent sample handling and normalization help reduce run-to-run drift.\u003c\/p\u003e\n\u003cp\u003eFollowing P-glycoprotein across perturbations can help separate expression effects from compartment shifts.\u003c\/p\u003e\n\u003ch2\u003eExperimental Applications\u003c\/h2\u003e\n\u003cp\u003eIn cultured models, junctional readouts can change rapidly after calcium modulation or cytoskeletal perturbation. Define inclusion criteria and controls early so replicate sets remain interpretable as the dataset grows.\u003c\/p\u003e\n\u003cp\u003eTarget-centric readouts can be framed around localization, relative abundance, or complex behavior, depending on the question you are testing. Blood-brain barrier models often monitor junction regulation alongside permeability-focused measurements.\u003c\/p\u003e\n\u003cp\u003eCommon experimental questions that benefit from target tracking include:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003ecomparative profiling across cell states or perturbations\u003c\/li\u003e\n\u003cli\u003eco-localization patterns with cytoskeletal elements\u003c\/li\u003e\n\u003cli\u003esubcellular redistribution at contact sites versus cytoplasm\u003c\/li\u003e\n\u003cli\u003echanges in complex assembly with scaffold or adaptor proteins\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eWorkflow Perspective\u003c\/h2\u003e\n\u003cp\u003eWhen samples are prepared in reducing conditions, some epitopes become more accessible; this version is designed with that context in mind. To keep comparisons consistent, align sample preparation steps and define a clear baseline for each series. Document normalization choices so collaborators can reproduce the same interpretation.\u003c\/p\u003e\n\u003cp\u003eTo support downstream analysis, record key context variables (culture timing, stimulation window, and extraction approach) so P-glycoprotein patterns can be compared across experiments without guesswork.\u003c\/p\u003e\n\u003cp\u003eFor multi-run studies, the denaturing-format option helps keep P-glycoprotein trends comparable from experiment to experiment.\u003c\/p\u003e","brand":"BiCell Scientific","offers":[{"title":"50 µl \/ No Blocker","offer_id":58101684109657,"sku":"31705-WB-50UL","price":500.0,"currency_code":"EUR","in_stock":true},{"title":"50 µl \/ 1 µg","offer_id":58101684142425,"sku":"31705-WB-50UL+1UG","price":569.0,"currency_code":"EUR","in_stock":true},{"title":"50 µl \/ 10 µg","offer_id":58101684175193,"sku":"31705-WB-50UL+10UG","price":619.0,"currency_code":"EUR","in_stock":true},{"title":"200 µl \/ No Blocker","offer_id":58101684207961,"sku":"31705-WB-200UL","price":1110.0,"currency_code":"EUR","in_stock":true},{"title":"200 µl \/ 1 µg","offer_id":58101684240729,"sku":"31705-WB-200UL+1UG","price":1179.0,"currency_code":"EUR","in_stock":true},{"title":"200 µl \/ 10 µg","offer_id":58101684273497,"sku":"31705-WB-200UL+10UG","price":1229.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/mdr1-brain-pfa.jpg?v=1779281052","url":"https:\/\/absource.de\/products\/p-glycoprotein-mdr1-or-abcb1-or-cd243-antibody-western-blot-validated","provider":"Absource Diagnostics","version":"1.0","type":"link"}