{"product_id":"p14-antibody-sc-f1711","title":"S100A9 + Calprotectin (S100A8\/A9 complex) Antibody","description":"\u003ch2\u003eAbout the Target\u003c\/h2\u003e\u003cp\u003eS100A9 + Calprotectin (S100A8\/A9 complex) also known as myeloid-related proteins MRP8\/MRP14, is a Ca²⁺-binding heterodimeric complex composed of S100A8 and S100A9, both members of the S100 protein family. Predominantly expressed in neutrophils, monocytes, and other immune cells, its expression is induced under inflammatory and stress conditions. Depending on the literature source, P14 may also be discussed as S100A9 + Calprotectin (S100A8\/A9 complex) and CAGB.\u003c\/p\u003e\u003cp\u003eReported cellular context includes cell membran, cytoplasm, cytoskeleton, and membrane, which can matter when signal is compared across treatments or changing cell states. Following P14 across matched perturbations can help separate abundance effects from shifts in localization, complex assembly, or pathway state.\u003c\/p\u003e\u003ch2\u003eResearch Context\u003c\/h2\u003e\u003cp\u003eP14 is commonly interpreted in the context of cancer, immunology, and inflammation research, and readouts are often stronger when a study separates expression changes from compartment-level redistribution. When reported signal spans cell membran, cytoplasm, and cytoskeleton, a defined reference condition can make comparisons more interpretable across perturbations, passages, or replicate sets.\u003c\/p\u003e\u003cp\u003eConsider these angles when interpreting target-level changes:\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eapparent redistribution between cell membran, cytoplasm, and cytoskeleton across matched conditions\u003c\/li\u003e\n\u003cli\u003echanges associated with proliferative state, oncogenic signaling, or treatment response\u003c\/li\u003e\n\u003cli\u003econtext differences tied to immune-cell state, activation, or lineage composition\u003c\/li\u003e\n\u003cli\u003eresponses associated with cytokine exposure, inflammatory tone, or tissue stress\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eVariant Considerations\u003c\/h2\u003e\u003cp\u003eIf your project spans exploratory questions, the regular version offers a balanced option for establishing baseline signal behavior for P14. This can help when protocols evolve over time and the goal is to compare experiments using a stable reference workflow.\u003c\/p\u003e\u003cp\u003eStandardize sampling time, control choice, and downstream analysis thresholds so apparent differences in P14 reflect biology rather than handling. When interpreting P14, it is often useful to decide early whether the main question is overall abundance, compartmental enrichment, or context-dependent redistribution.\u003c\/p\u003e\u003cp\u003eFor multi-run studies, a shared reference condition can keep P14 trends easier to compare across datasets. That kind of consistency is especially helpful when follow-up work expands to new perturbations, model systems, or longitudinal collections.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"20 µl","offer_id":57577828942169,"sku":"F1711-20UL","price":199.0,"currency_code":"EUR","in_stock":true},{"title":"100 µl","offer_id":57577828974937,"sku":"F1711-100UL","price":489.0,"currency_code":"EUR","in_stock":true},{"title":"2 × 100 µl","offer_id":57577829007705,"sku":"F1711-2X100UL","price":729.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/F1711-IHC1.jpg?v=1773600063","url":"https:\/\/absource.de\/products\/p14-antibody-sc-f1711","provider":"Absource Diagnostics","version":"1.0","type":"link"}