{"product_id":"p36-antibody-sc-f4062","title":"Annexin-2\/ANXA2 Antibody","description":"\u003ch2\u003eAbout the Target\u003c\/h2\u003e\u003cp\u003eP36 is a target of interest in many antibody-based workflows. Annexin-2\/ANXA2 is a multifunctional, pleiotropic calcium- and anionic, phospholipid-binding protein of the annexin family that exists as a monomer or as a heterotetrameric complex (AIIt) with S100A10. Structurally, ANXA2 contains an N-terminal head domain, which undergoes post-translational modifications (acetylation, phosphorylation) and mediates interactions with S100A10, tissue plasminogen activator (tPA), and other proteins, and a conserved C-terminal core domain composed of four annexin repeats (~70 amino acids each) that bind Ca²⁺, phospholipids, heparin, RNA, and F-actin. Depending on the literature source, P36 may also be discussed as Annexin-2\/ANXA2 and ANX2.\u003c\/p\u003e\u003cp\u003eReported cellular context includes basement membrane, extracellular matrix, and secreted, which can matter when signal is compared across treatments or changing cell states. Following P36 across matched perturbations can help separate abundance effects from shifts in localization, complex assembly, or pathway state.\u003c\/p\u003e\u003ch2\u003eResearch Context\u003c\/h2\u003e\u003cp\u003eP36 is commonly interpreted in the context of cancer, neuroscience, and metabolism research, and readouts are often stronger when a study separates expression changes from compartment-level redistribution. When reported signal spans basement membrane, extracellular matrix, and secreted, a defined reference condition can make comparisons more interpretable across perturbations, passages, or replicate sets.\u003c\/p\u003e\u003cp\u003eConsider these angles when interpreting target-level changes:\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eapparent redistribution between basement membrane, extracellular matrix, and secreted across matched conditions\u003c\/li\u003e\n\u003cli\u003echanges associated with proliferative state, oncogenic signaling, or treatment response\u003c\/li\u003e\n\u003cli\u003ecompartment-specific patterns relevant to neuronal polarity, transport, or synaptic context\u003c\/li\u003e\n\u003cli\u003eresponses linked to nutrient status, mitochondrial state, or metabolic rewiring\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eVariant Considerations\u003c\/h2\u003e\u003cp\u003eIf your project spans exploratory questions, the regular version offers a balanced option for establishing baseline signal behavior for P36. This can help when protocols evolve over time and the goal is to compare experiments using a stable reference workflow.\u003c\/p\u003e\u003cp\u003eStandardize sampling time, control choice, and downstream analysis thresholds so apparent differences in P36 reflect biology rather than handling. When interpreting P36, it is often useful to decide early whether the main question is overall abundance, compartmental enrichment, or context-dependent redistribution.\u003c\/p\u003e\u003cp\u003eFor multi-run studies, a shared reference condition can keep P36 trends easier to compare across datasets. That kind of consistency is especially helpful when follow-up work expands to new perturbations, model systems, or longitudinal collections.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"20 µl","offer_id":57578056417625,"sku":"F4062-20UL","price":199.0,"currency_code":"EUR","in_stock":true},{"title":"100 µl","offer_id":57578056450393,"sku":"F4062-100UL","price":489.0,"currency_code":"EUR","in_stock":true},{"title":"2 × 100 µl","offer_id":57578056483161,"sku":"F4062-2X100UL","price":729.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/F4062-IF.png?v=1773601631","url":"https:\/\/absource.de\/products\/p36-antibody-sc-f4062","provider":"Absource Diagnostics","version":"1.0","type":"link"}