{"product_id":"pdgfr-alpha-antibody-sc-f3240","title":"PDGFR α Antibody","description":"\u003ch2\u003eAbout the Target\u003c\/h2\u003e\u003cp\u003ePDGFR-ALPHA is a target of interest in many antibody-based workflows. PDGFRα (Platelet-derived growth factor receptor alpha) is a type III receptor tyrosine kinase characterized by five extracellular immunoglobulin (Ig)-like domains, a single transmembrane domain, and an intracellular region containing a split kinase domain with a unique inserted sequence, a juxtamembrane domain, and a variable C-terminal tail. Activated by ligand-induced dimerization and autophosphorylation, PDGFRα forms homo- or heterodimers (e. g., with PDGFRβ) upon binding PDGF ligands, excluding PDGF-D. Depending on the literature source, PDGFR-ALPHA may also be discussed as PDGFR alpha and Platelet-derived growth factor receptor alpha; PDGF-R-alpha; PDGFR-alpha; Alpha platelet-derived growth factor receptor; Alpha-type platelet-derived growth factor receptor.\u003c\/p\u003e\u003cp\u003eReported cellular context includes cellmembrane, golgiapparatus, and membrane, which can matter when signal is compared across treatments or changing cell states. Following PDGFR-ALPHA across matched perturbations can help separate abundance effects from shifts in localization, complex assembly, or pathway state.\u003c\/p\u003e\u003ch2\u003eResearch Context\u003c\/h2\u003e\u003cp\u003ePDGFR-ALPHA is commonly interpreted in the context of immunology, developmental biology, and cell signaling research, and readouts are often stronger when a study separates expression changes from compartment-level redistribution. When reported signal spans cellmembrane, golgiapparatus, and membrane, a defined reference condition can make comparisons more interpretable across perturbations, passages, or replicate sets.\u003c\/p\u003e\u003cp\u003eConsider these angles when interpreting target-level changes:\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eapparent redistribution between cellmembrane, golgiapparatus, and membrane across matched conditions\u003c\/li\u003e\n\u003cli\u003econtext differences tied to immune-cell state, activation, or lineage composition\u003c\/li\u003e\n\u003cli\u003estage-dependent patterns during differentiation, morphogenesis, or lineage commitment\u003c\/li\u003e\n\u003cli\u003esignal-dependent shifts after ligand, inhibitor, or growth-factor perturbation\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eVariant Considerations\u003c\/h2\u003e\u003cp\u003eIf your project spans exploratory questions, the regular version offers a balanced option for establishing baseline signal behavior for PDGFR-ALPHA. This can help when protocols evolve over time and the goal is to compare experiments using a stable reference workflow.\u003c\/p\u003e\u003cp\u003eStandardize sampling time, control choice, and downstream analysis thresholds so apparent differences in PDGFR-ALPHA reflect biology rather than handling. When interpreting PDGFR-ALPHA, it is often useful to decide early whether the main question is overall abundance, compartmental enrichment, or context-dependent redistribution.\u003c\/p\u003e\u003cp\u003eFor multi-run studies, a shared reference condition can keep PDGFR-ALPHA trends easier to compare across datasets. That kind of consistency is especially helpful when follow-up work expands to new perturbations, model systems, or longitudinal collections.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"20 µl","offer_id":57578011165017,"sku":"F3240-20UL","price":199.0,"currency_code":"EUR","in_stock":true},{"title":"100 µl","offer_id":57578011197785,"sku":"F3240-100UL","price":489.0,"currency_code":"EUR","in_stock":true},{"title":"2 × 100 µl","offer_id":57578011230553,"sku":"F3240-2X100UL","price":729.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/F3240-IF.png?v=1773601053","url":"https:\/\/absource.de\/products\/pdgfr-alpha-antibody-sc-f3240","provider":"Absource Diagnostics","version":"1.0","type":"link"}