{"product_id":"pgrmc1-antibody-sc-f1408","title":"PGRMC1 Antibody","description":"\u003ch2\u003eAbout the Target\u003c\/h2\u003e\u003cp\u003eProgesterone receptor membrane component 1 (PGRMC1) is a highly conserved heme-binding protein primarily found in the liver and kidney but also expressed in various tissues such as the brain, breast, lung, pancreas, and reproductive organs. PGRMC1 plays a significant role in carcinogenesis, particularly in breast cancer, making it a potential target for cancer therapy.\u003c\/p\u003e\u003cp\u003eReported cellular context includes endoplasmic reticulum, membrane, microsome, and mitochondrion, which can matter when signal is compared across treatments or changing cell states. Following PGRMC1 across matched perturbations can help separate abundance effects from shifts in localization, complex assembly, or pathway state.\u003c\/p\u003e\u003ch2\u003eResearch Context\u003c\/h2\u003e\u003cp\u003ePGRMC1 is commonly interpreted in the context of cancer and cell signaling research, and readouts are often stronger when a study separates expression changes from compartment-level redistribution. When reported signal spans endoplasmic reticulum, membrane, and microsome, a defined reference condition can make comparisons more interpretable across perturbations, passages, or replicate sets.\u003c\/p\u003e\u003cp\u003eConsider these angles when interpreting target-level changes:\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eapparent redistribution between endoplasmic reticulum, membrane, and microsome across matched conditions\u003c\/li\u003e\n\u003cli\u003echanges associated with proliferative state, oncogenic signaling, or treatment response\u003c\/li\u003e\n\u003cli\u003esignal-dependent shifts after ligand, inhibitor, or growth-factor perturbation\u003c\/li\u003e\n\u003cli\u003eco-patterning with orthogonal markers and control conditions that clarify pathway state\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eVariant Considerations\u003c\/h2\u003e\u003cp\u003eIf your project spans exploratory questions, the regular version offers a balanced option for establishing baseline signal behavior for PGRMC1. This can help when protocols evolve over time and the goal is to compare experiments using a stable reference workflow.\u003c\/p\u003e\u003cp\u003eStandardize sampling time, control choice, and downstream analysis thresholds so apparent differences in PGRMC1 reflect biology rather than handling. When interpreting PGRMC1, it is often useful to decide early whether the main question is overall abundance, compartmental enrichment, or context-dependent redistribution.\u003c\/p\u003e\u003cp\u003eFor multi-run studies, a shared reference condition can keep PGRMC1 trends easier to compare across datasets. That kind of consistency is especially helpful when follow-up work expands to new perturbations, model systems, or longitudinal collections.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"Selleck \/ 20 µl","offer_id":57577725985113,"sku":"F1408-20UL","price":149.0,"currency_code":"EUR","in_stock":true},{"title":"Selleck \/ 100 µl","offer_id":57577726017881,"sku":"F1408-100UL","price":359.0,"currency_code":"EUR","in_stock":true},{"title":"Selleck \/ 2 × 100 µl","offer_id":57577726050649,"sku":"F1408-2X100UL","price":539.0,"currency_code":"EUR","in_stock":true},{"title":"Capsid \/ 20 µl","offer_id":58449994383705,"sku":"C05829-20UL","price":116.0,"currency_code":"EUR","in_stock":true},{"title":"Capsid \/ 100 µl","offer_id":58449994416473,"sku":"C05829-100UL","price":293.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/F1408-IHC1.jpg?v=1773599710","url":"https:\/\/absource.de\/products\/pgrmc1-antibody-sc-f1408","provider":"Absource Diagnostics","version":"1.0","type":"link"}