{"product_id":"ph-064-s3451","title":"PH-064","description":"\u003cp\u003e\u003cstrong\u003ePH-064\u003c\/strong\u003e is an inhibitor of GPR used in studies of Wnt Signaling and GPCR Signaling. In practice, this places the compound in experiments that measure beta-catenin-dependent transcription and developmental signaling and receptor-driven second-messenger signaling and desensitization dynamics in cell signaling and developmental biology models.\u003c\/p\u003e\n\n\u003cp\u003eBy inhibiting GPR, PH-064 can be used to examine beta-catenin-dependent transcription and developmental signaling and receptor-driven second-messenger signaling and desensitization dynamics. The gpcr annotation adds relevance to GPCR pharmacology, ligand-binding, and signaling assays, together with downstream-response mapping in the same experimental setting. In cell signaling and developmental biology models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.\u003c\/p\u003e\n\n\u003ch2\u003eResearch Applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eTarget-focused assays involving GPR\u003c\/li\u003e\n\u003cli\u003ePathway perturbation studies connected to Wnt Signaling and GPCR Signaling\u003c\/li\u003e\n\u003cli\u003eConcentration-response inhibition and target-dependence studies\u003c\/li\u003e\n\u003cli\u003eGPCR pharmacology, ligand-binding, and signaling assays\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003eOverall, PH-064 is appropriate when a defined chemical perturbant is needed to connect GPR with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in cell signaling and developmental biology models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"5 mg","offer_id":57808897409369,"sku":"S3451-5MG","price":409.0,"currency_code":"EUR","in_stock":true},{"title":"25 mg","offer_id":57808897442137,"sku":"S3451-25MG","price":953.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/s3451-ph-064-bim-46187-chemical-structure.png?v=1776194956","url":"https:\/\/absource.de\/products\/ph-064-s3451","provider":"Absource Diagnostics","version":"1.0","type":"link"}