{"product_id":"pi3-kinase-p85alpha-antibody-sc-f1720","title":"PI3 Kinase p85α Antibody","description":"\u003ch2\u003eAbout the Target\u003c\/h2\u003e\u003cp\u003ePI3 Kinase P85ALPHA is a target of interest in many antibody-based workflows. Phosphoinositide 3-kinase (PI3K) p85α is a regulatory subunit essential for controlling the PI3K signaling pathway, pivotal in regulating cell growth, survival, and metabolism. p85α interacts with the catalytic subunit p110 of PI3K, inhibiting p110's activity in its basal state and stabilizing it for controlled activation in response to cellular signals. This interaction is primarily mediated through the N-terminal SH2 domains of p85α, which bind to phosphorylated tyrosine residues on activated receptors. Depending on the literature source, PI3 Kinase P85ALPHA may also be discussed as PI3K p85alpha.\u003c\/p\u003e\u003cp\u003eReported cellular context includes cell membrane, cell junction, cytoplasm, and cytosol, which can matter when signal is compared across treatments or changing cell states. Following PI3 Kinase P85ALPHA across matched perturbations can help separate abundance effects from shifts in localization, complex assembly, or pathway state.\u003c\/p\u003e\u003ch2\u003eResearch Context\u003c\/h2\u003e\u003cp\u003ePI3 Kinase P85ALPHA is commonly interpreted in the context of cancer, metabolism, and cell signaling research, and readouts are often stronger when a study separates expression changes from compartment-level redistribution. When reported signal spans cell membrane, cell junction, and cytoplasm, a defined reference condition can make comparisons more interpretable across perturbations, passages, or replicate sets.\u003c\/p\u003e\u003cp\u003eConsider these angles when interpreting target-level changes:\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eapparent redistribution between cell membrane, cell junction, and cytoplasm across matched conditions\u003c\/li\u003e\n\u003cli\u003echanges associated with proliferative state, oncogenic signaling, or treatment response\u003c\/li\u003e\n\u003cli\u003eresponses linked to nutrient status, mitochondrial state, or metabolic rewiring\u003c\/li\u003e\n\u003cli\u003esignal-dependent shifts after ligand, inhibitor, or growth-factor perturbation\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eVariant Considerations\u003c\/h2\u003e\u003cp\u003eIf your project spans exploratory questions, the regular version offers a balanced option for establishing baseline signal behavior for PI3 Kinase P85ALPHA. This can help when protocols evolve over time and the goal is to compare experiments using a stable reference workflow.\u003c\/p\u003e\u003cp\u003eStandardize sampling time, control choice, and downstream analysis thresholds so apparent differences in PI3 Kinase P85ALPHA reflect biology rather than handling. When interpreting PI3 Kinase P85ALPHA, it is often useful to decide early whether the main question is overall abundance, compartmental enrichment, or context-dependent redistribution.\u003c\/p\u003e\u003cp\u003eFor multi-run studies, a shared reference condition can keep PI3 Kinase P85ALPHA trends easier to compare across datasets. That kind of consistency is especially helpful when follow-up work expands to new perturbations, model systems, or longitudinal collections.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"20 µl","offer_id":57577831596377,"sku":"F1720-20UL","price":149.0,"currency_code":"EUR","in_stock":true},{"title":"100 µl","offer_id":57577831629145,"sku":"F1720-100UL","price":319.0,"currency_code":"EUR","in_stock":true},{"title":"2 × 100 µl","offer_id":57577831661913,"sku":"F1720-2X100UL","price":479.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/F1720-IHC1.jpg?v=1773600070","url":"https:\/\/absource.de\/products\/pi3-kinase-p85alpha-antibody-sc-f1720","provider":"Absource Diagnostics","version":"1.0","type":"link"}