{"product_id":"pik-75-hcl-s1205","title":"PIK-75 HCl","description":"\u003cp\u003e\u003cstrong\u003ePIK-75 HCl\u003c\/strong\u003e is an inhibitor of PI3K and DNA-PK used in studies of PI3K-Akt-mTOR Signaling and DNA Damage Response. In practice, this places the compound in experiments that measure growth-factor signaling, survival control, and nutrient-sensing outputs and checkpoint activation, DNA repair, and genome-stability control in cancer, cell signaling, and dna damage \/ repair models.\u003c\/p\u003e\n\n\u003cp\u003eBy inhibiting PI3K and DNA-PK, PIK-75 HCl can be used to examine growth-factor signaling, survival control, and nutrient-sensing outputs and checkpoint activation, DNA repair, and genome-stability control. The kinase annotation adds relevance to biochemical kinase assays, phospho-signaling studies, and selectivity profiling, together with downstream-response mapping in the same experimental setting. In cancer, cell signaling, and dna damage \/ repair models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.\u003c\/p\u003e\n\n\u003ch2\u003eResearch Applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eTarget-focused assays involving PI3K and DNA-PK\u003c\/li\u003e\n\u003cli\u003ePathway perturbation studies connected to PI3K-Akt-mTOR Signaling and DNA Damage Response\u003c\/li\u003e\n\u003cli\u003eConcentration-response inhibition and target-dependence studies\u003c\/li\u003e\n\u003cli\u003eBiochemical kinase assays, phospho-signaling studies, and selectivity profiling\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003eOverall, PIK-75 HCl is appropriate when a defined chemical perturbant is needed to connect PI3K and DNA-PK with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in cancer, cell signaling, and dna damage \/ repair models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"Selleck \/ 10 mg","offer_id":57805244825945,"sku":"S1205-10MG","price":144.0,"currency_code":"EUR","in_stock":true},{"title":"Selleck \/ 100 mg","offer_id":57805244858713,"sku":"S1205-100MG","price":481.0,"currency_code":"EUR","in_stock":true},{"title":"Capsid \/ 10 mg","offer_id":58478421213529,"sku":"C07613-10MG","price":108.0,"currency_code":"EUR","in_stock":true},{"title":"Capsid \/ 100 mg","offer_id":58478421246297,"sku":"C16185-100MG","price":360.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/PIK-75-chemical-structure-S1205.gif?v=1776173110","url":"https:\/\/absource.de\/products\/pik-75-hcl-s1205","provider":"Absource Diagnostics","version":"1.0","type":"link"}