{"product_id":"pim1-antibody-sc-f0857","title":"Pim-1 Antibody","description":"\u003ch2\u003eAbout the Target\u003c\/h2\u003e\u003cp\u003ePIM1 is a target of interest in many antibody-based workflows. Pim proteins (Pim-1, Pim-2, and Pim-3) are serine\/threonine kinases encoded by oncogenes. Pim-1, predominantly expressed in hematopoietic cells, plays a pivotal role in transmitting mitogenic signals and is swiftly induced by various growth factors and cytokines. It collaborates with c-Myc in transforming lymphoid cells and shields cells from apoptosis triggered by growth factor deprivation and genotoxic stress. Depending on the literature source, PIM1 may also be discussed as Pim-1.\u003c\/p\u003e\u003cp\u003eReported cellular context includes cell membrane, cytoplasm, membrane, and nucleus, which can matter when signal is compared across treatments or changing cell states. Following PIM1 across matched perturbations can help separate abundance effects from shifts in localization, complex assembly, or pathway state.\u003c\/p\u003e\u003ch2\u003eResearch Context\u003c\/h2\u003e\u003cp\u003ePIM1 is commonly interpreted in the context of immunology research, and readouts are often stronger when a study separates expression changes from compartment-level redistribution. When reported signal spans cell membrane, cytoplasm, and membrane, a defined reference condition can make comparisons more interpretable across perturbations, passages, or replicate sets.\u003c\/p\u003e\u003cp\u003eConsider these angles when interpreting target-level changes:\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eapparent redistribution between cell membrane, cytoplasm, and membrane across matched conditions\u003c\/li\u003e\n\u003cli\u003econtext differences tied to immune-cell state, activation, or lineage composition\u003c\/li\u003e\n\u003cli\u003eco-patterning with orthogonal markers and control conditions that clarify pathway state\u003c\/li\u003e\n\u003cli\u003etime-matched comparisons so changes reflect biology rather than handling or sampling drift\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eVariant Considerations\u003c\/h2\u003e\u003cp\u003eIf your project spans exploratory questions, the regular version offers a balanced option for establishing baseline signal behavior for PIM1. This can help when protocols evolve over time and the goal is to compare experiments using a stable reference workflow.\u003c\/p\u003e\u003cp\u003eStandardize sampling time, control choice, and downstream analysis thresholds so apparent differences in PIM1 reflect biology rather than handling. When interpreting PIM1, it is often useful to decide early whether the main question is overall abundance, compartmental enrichment, or context-dependent redistribution.\u003c\/p\u003e\u003cp\u003eFor multi-run studies, a shared reference condition can keep PIM1 trends easier to compare across datasets. That kind of consistency is especially helpful when follow-up work expands to new perturbations, model systems, or longitudinal collections.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"20 µl","offer_id":57577533571417,"sku":"F0857-20UL","price":149.0,"currency_code":"EUR","in_stock":true},{"title":"100 µl","offer_id":57577533604185,"sku":"F0857-100UL","price":329.0,"currency_code":"EUR","in_stock":true},{"title":"2 × 100 µl","offer_id":57577533636953,"sku":"F0857-2X100UL","price":489.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/F0857-wb.gif?v=1773599017","url":"https:\/\/absource.de\/products\/pim1-antibody-sc-f0857","provider":"Absource Diagnostics","version":"1.0","type":"link"}