{"product_id":"pim447-e8144","title":"PIM447","description":"\u003cp\u003e\u003cstrong\u003ePIM447\u003c\/strong\u003e is an inhibitor of PIM used in studies of JAK-STAT Signaling and Cell Cycle Regulation and related signaling programs. In practice, this places the compound in experiments that measure cytokine-responsive transcriptional signaling and immune regulation and checkpoint control, mitotic progression, and proliferation timing in apoptosis, cancer, and cell signaling models.\u003c\/p\u003e\n\n\u003cp\u003eBy inhibiting PIM, PIM447 can be used to examine cytokine-responsive transcriptional signaling and immune regulation and checkpoint control, mitotic progression, and proliferation timing. The kinase annotation adds relevance to biochemical kinase assays, phospho-signaling studies, and selectivity profiling, together with downstream-response mapping in the same experimental setting. In apoptosis, cancer, and cell signaling models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.\u003c\/p\u003e\n\n\u003ch2\u003eResearch Applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eTarget-focused assays involving PIM\u003c\/li\u003e\n\u003cli\u003ePathway perturbation studies connected to JAK-STAT Signaling and Cell Cycle Regulation and related signaling programs\u003c\/li\u003e\n\u003cli\u003eConcentration-response inhibition and target-dependence studies\u003c\/li\u003e\n\u003cli\u003eBiochemical kinase assays, phospho-signaling studies, and selectivity profiling\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003eOverall, PIM447 is appropriate when a defined chemical perturbant is needed to connect PIM with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in apoptosis, cancer, and cell signaling models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"Default Title","offer_id":57818737738073,"sku":"E8144","price":0.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/e8144-pim447-chemical-structure-tube.png?v=1776276294","url":"https:\/\/absource.de\/products\/pim447-e8144","provider":"Absource Diagnostics","version":"1.0","type":"link"}