{"product_id":"pk-11195-e4637","title":"PK 11195","description":"\u003cp\u003e\u003cstrong\u003ePK 11195\u003c\/strong\u003e is an antagonist of PXR used in studies of Metabolic Signaling. In practice, this places the compound in experiments that measure metabolic regulation, energy sensing, and enzyme-linked homeostasis in endocrinology and metabolism models.\u003c\/p\u003e\n\n\u003cp\u003eBy blocking PXR, PK 11195 can be used to examine metabolic regulation, energy sensing, and enzyme-linked homeostasis. The nuclear receptor annotation adds relevance to reporter-gene, receptor-binding, and transcriptional assays, together with downstream-response mapping in the same experimental setting. In endocrinology and metabolism models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.\u003c\/p\u003e\n\n\u003ch2\u003eResearch Applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eTarget-focused assays involving PXR\u003c\/li\u003e\n\u003cli\u003ePathway perturbation studies connected to Metabolic Signaling\u003c\/li\u003e\n\u003cli\u003eReceptor-blockade and ligand-competition studies\u003c\/li\u003e\n\u003cli\u003eReporter-gene, receptor-binding, and transcriptional assays\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003eOverall, PK 11195 is appropriate when a defined chemical perturbant is needed to connect PXR with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in endocrinology and metabolism models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"Default Title","offer_id":57818430538073,"sku":"E4637","price":0.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/E4637-PK-11195-chemical-structure.png?v=1776275122","url":"https:\/\/absource.de\/products\/pk-11195-e4637","provider":"Absource Diagnostics","version":"1.0","type":"link"}