{"product_id":"pkar2-pkr2-antibody-sc-f2119","title":"Phospho-PKAR2\/PKR2 (Ser99) Antibody","description":"\u003ch2\u003eAbout the Target\u003c\/h2\u003e\u003cp\u003ePhospho-PKAR2\/PKR2 (Ser99) is a target of interest in many antibody-based workflows. Prokineticins are signaling molecules that play roles in a range of physiological processes, including gastrointestinal motility, circadian rhythms, emotions, pain perception, angiogenesis, and neurogenesis. They exert their effects by binding to two related G protein-coupled receptors (GPCRs), PKR1 and PKR2. Activation of these prokineticin receptors (PKRs) results in the accumulation of inositol phosphate and the mobilization of intracellular Ca2+ through Gαq\/11 proteins. Depending on the literature source, Phospho-PKAR2\/PKR2 (Ser99) may also be discussed as Phospho-PKAR2\/PKR2 (Ser99) and Phospho PKA R2 (Ser 99).\u003c\/p\u003e\u003cp\u003eReported cellular context includes cell membrane, cytoplasm, and membrane, which can matter when signal is compared across treatments or changing cell states. Following Phospho-PKAR2\/PKR2 (Ser99) across matched perturbations can help separate abundance effects from shifts in localization, complex assembly, or pathway state.\u003c\/p\u003e\u003ch2\u003eResearch Context\u003c\/h2\u003e\u003cp\u003ePhospho-PKAR2\/PKR2 (Ser99) is commonly interpreted in the context of cell signaling research, and readouts are often stronger when a study separates expression changes from compartment-level redistribution. When reported signal spans cell membrane, cytoplasm, and membrane, a defined reference condition can make comparisons more interpretable across perturbations, passages, or replicate sets.\u003c\/p\u003e\u003cp\u003eConsider these angles when interpreting target-level changes:\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eapparent redistribution between cell membrane, cytoplasm, and membrane across matched conditions\u003c\/li\u003e\n\u003cli\u003esignal-dependent shifts after ligand, inhibitor, or growth-factor perturbation\u003c\/li\u003e\n\u003cli\u003edifferences between total target abundance and site-specific regulation when modified forms are compared\u003c\/li\u003e\n\u003cli\u003eco-patterning with orthogonal markers and control conditions that clarify pathway state\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eVariant Considerations\u003c\/h2\u003e\u003cp\u003eIf your project spans exploratory questions, the regular version offers a balanced option for establishing baseline signal behavior for Phospho-PKAR2\/PKR2 (Ser99). This can help when protocols evolve over time and the goal is to compare experiments using a stable reference workflow.\u003c\/p\u003e\u003cp\u003eStandardize sampling time, control choice, and downstream analysis thresholds so apparent differences in Phospho-PKAR2\/PKR2 (Ser99) reflect biology rather than handling. When interpreting Phospho-PKAR2\/PKR2 (Ser99), it is often useful to decide early whether the main question is overall abundance, compartmental enrichment, or context-dependent redistribution.\u003c\/p\u003e\u003cp\u003eFor multi-run studies, a shared reference condition can keep Phospho-PKAR2\/PKR2 (Ser99) trends easier to compare across datasets. That kind of consistency is especially helpful when follow-up work expands to new perturbations, model systems, or longitudinal collections.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"Selleck \/ 20 µl","offer_id":57577867706713,"sku":"F2119-20UL","price":199.0,"currency_code":"EUR","in_stock":true},{"title":"Selleck \/ 100 µl","offer_id":57577867739481,"sku":"F2119-100UL","price":489.0,"currency_code":"EUR","in_stock":true},{"title":"Selleck \/ 2 × 100 µl","offer_id":57577867772249,"sku":"F2119-2X100UL","price":729.0,"currency_code":"EUR","in_stock":true},{"title":"Capsid \/ 20 µl","offer_id":58477345341785,"sku":"C06093-20UL","price":166.0,"currency_code":"EUR","in_stock":true},{"title":"Capsid \/ 100 µl","offer_id":58477345374553,"sku":"C06093-100UL","price":392.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/F2119-IF.jpg?v=1773600195","url":"https:\/\/absource.de\/products\/pkar2-pkr2-antibody-sc-f2119","provider":"Absource Diagnostics","version":"1.0","type":"link"}