{"product_id":"plk1-antibody-sc-f0393","title":"PLK1 Antibody","description":"\u003ch2\u003eAbout the Target\u003c\/h2\u003e\u003cp\u003ePLK1 (Polo-like kinase 1), classified as a serine\/threonine kinase, orchestrates a wide array of biological functions by phosphorylating over 600 substrates. These functions span across mitosis, apoptosis, metabolism, RNA processing, vesicle transport, and G2 DNA-damage checkpoint recovery. The PLK1 protein comprises a kinase domain (KD) at its N-terminus and a polo-box domain (PBD) at its C-terminus. Depending on the literature source, PLK1 may also be discussed as Plk.\u003c\/p\u003e\u003cp\u003eReported cellular context includes centromere, chromosome, cytoplasm, and cytoskeleton, which can matter when signal is compared across treatments or changing cell states. Following PLK1 across matched perturbations can help separate abundance effects from shifts in localization, complex assembly, or pathway state.\u003c\/p\u003e\u003ch2\u003eResearch Context\u003c\/h2\u003e\u003cp\u003ePLK1 is commonly interpreted in the context of cancer, cell cycle, and cell signaling research, and readouts are often stronger when a study separates expression changes from compartment-level redistribution. When reported signal spans centromere, chromosome, and cytoplasm, a defined reference condition can make comparisons more interpretable across perturbations, passages, or replicate sets.\u003c\/p\u003e\u003cp\u003eConsider these angles when interpreting target-level changes:\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eapparent redistribution between centromere, chromosome, and cytoplasm across matched conditions\u003c\/li\u003e\n\u003cli\u003echanges associated with proliferative state, oncogenic signaling, or treatment response\u003c\/li\u003e\n\u003cli\u003ecell-cycle linked differences in abundance, timing, or compartmental enrichment\u003c\/li\u003e\n\u003cli\u003esignal-dependent shifts after ligand, inhibitor, or growth-factor perturbation\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eVariant Considerations\u003c\/h2\u003e\u003cp\u003eIf your project spans exploratory questions, the regular version offers a balanced option for establishing baseline signal behavior for PLK1. This can help when protocols evolve over time and the goal is to compare experiments using a stable reference workflow.\u003c\/p\u003e\u003cp\u003eStandardize sampling time, control choice, and downstream analysis thresholds so apparent differences in PLK1 reflect biology rather than handling. When interpreting PLK1, it is often useful to decide early whether the main question is overall abundance, compartmental enrichment, or context-dependent redistribution.\u003c\/p\u003e\u003cp\u003eFor multi-run studies, a shared reference condition can keep PLK1 trends easier to compare across datasets. That kind of consistency is especially helpful when follow-up work expands to new perturbations, model systems, or longitudinal collections.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"Selleck \/ 20 µl","offer_id":57577449193817,"sku":"F0393-20UL","price":139.0,"currency_code":"EUR","in_stock":true},{"title":"Selleck \/ 100 µl","offer_id":57577449226585,"sku":"F0393-100UL","price":329.0,"currency_code":"EUR","in_stock":true},{"title":"Selleck \/ 2 × 100 µl","offer_id":57577449259353,"sku":"F0393-2X100UL","price":489.0,"currency_code":"EUR","in_stock":true},{"title":"Capsid \/ 20 µl","offer_id":58433978532185,"sku":"C05157-20UL","price":116.0,"currency_code":"EUR","in_stock":true},{"title":"Capsid \/ 100 µl","offer_id":58433978564953,"sku":"C05157-100UL","price":264.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/F0393-IHC1.jpg?v=1773598412","url":"https:\/\/absource.de\/products\/plk1-antibody-sc-f0393","provider":"Absource Diagnostics","version":"1.0","type":"link"}