{"product_id":"plus-jq1-carboxylic-acid-s6993","title":"(+)-JQ1 carboxylic acid","description":"\u003cp\u003e\u003cstrong\u003e(+)-JQ1 carboxylic acid\u003c\/strong\u003e is a modulator of BET and E3 Ligase used in studies of Protein Degradation \/ Proteasome and Epigenetic Regulation. It is especially relevant in cancer, epigenetics, and protein homeostasis models, where defined compound exposure can be linked to ubiquitin-dependent turnover, proteostasis, and targeted protein degradation and chromatin-state control, histone modification, and transcriptional regulation.\u003c\/p\u003e\n\n\u003cp\u003eBy modulating BET and E3 Ligase, (+)-JQ1 carboxylic acid can be used to examine ubiquitin-dependent turnover, proteostasis, and targeted protein degradation and chromatin-state control, histone modification, and transcriptional regulation. The epigenetic regulator annotation adds relevance to chromatin, epigenetic, and gene-expression profiling, together with downstream-response mapping in the same experimental setting. In cancer, epigenetics, and protein homeostasis models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.\u003c\/p\u003e\n\n\u003ch2\u003eResearch Applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eTarget-focused assays involving BET and E3 Ligase\u003c\/li\u003e\n\u003cli\u003ePathway perturbation studies connected to Protein Degradation \/ Proteasome and Epigenetic Regulation\u003c\/li\u003e\n\u003cli\u003eContext-dependent response profiling and mechanism comparison\u003c\/li\u003e\n\u003cli\u003eChromatin, epigenetic, and gene-expression profiling\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003eOverall, (+)-JQ1 carboxylic acid is appropriate when a defined chemical perturbant is needed to connect BET and E3 Ligase with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in cancer, epigenetics, and protein homeostasis models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"5 mg","offer_id":57809444733273,"sku":"S6993-5MG","price":95.0,"currency_code":"EUR","in_stock":true},{"title":"25 mg","offer_id":57809444766041,"sku":"S6993-25MG","price":285.0,"currency_code":"EUR","in_stock":true},{"title":"1 ml (10mM\/DMSO)","offer_id":57809444798809,"sku":"S6993-1ML\/DMSO","price":114.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/s6993-jq-1-carboxylic-acid-chemical-structure.gif?v=1776200781","url":"https:\/\/absource.de\/products\/plus-jq1-carboxylic-acid-s6993","provider":"Absource Diagnostics","version":"1.0","type":"link"}