{"product_id":"pnpla2-antibody-sc-f3255","title":"ATGL Antibody","description":"\u003ch2\u003eAbout the Target\u003c\/h2\u003e\u003cp\u003ePNPLA2 is a target of interest in many antibody-based workflows. Adipose triglyceride lipase (ATGL) is a key enzyme in intracellular lipolysis, catalyzing the first step of triacylglycerol (TG) breakdown into diacylglycerol (DG) and free fatty acids (FAs) for energy production. Structurally, ATGL belongs to the patatin-like phospholipase domain-containing (PNPLA) family, containing a patatin-like domain (Ile10-Leu178) with a Ser47-Asp166 catalytic dyad responsible for its TG hydrolase activity. Depending on the literature source, PNPLA2 may also be discussed as ATGL and Adipose Triglyceride Lipase.\u003c\/p\u003e\u003cp\u003eReported cellular context includes cell membrane, cytoplasm, lipid droplet, and membrane, which can matter when signal is compared across treatments or changing cell states. Following PNPLA2 across matched perturbations can help separate abundance effects from shifts in localization, complex assembly, or pathway state.\u003c\/p\u003e\u003ch2\u003eResearch Context\u003c\/h2\u003e\u003cp\u003ePNPLA2 is commonly interpreted in the context of cardiovascular, metabolism, and endocrinology research, and readouts are often stronger when a study separates expression changes from compartment-level redistribution. When reported signal spans cell membrane, cytoplasm, and lipid droplet, a defined reference condition can make comparisons more interpretable across perturbations, passages, or replicate sets.\u003c\/p\u003e\u003cp\u003eConsider these angles when interpreting target-level changes:\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eapparent redistribution between cell membrane, cytoplasm, and lipid droplet across matched conditions\u003c\/li\u003e\n\u003cli\u003echanges linked to vascular, contractile, or hemodynamic cell-state cues\u003c\/li\u003e\n\u003cli\u003eresponses linked to nutrient status, mitochondrial state, or metabolic rewiring\u003c\/li\u003e\n\u003cli\u003eresponses to hormone-dependent signaling or endocrine feedback context\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eVariant Considerations\u003c\/h2\u003e\u003cp\u003eIf your project spans exploratory questions, the regular version offers a balanced option for establishing baseline signal behavior for PNPLA2. This can help when protocols evolve over time and the goal is to compare experiments using a stable reference workflow.\u003c\/p\u003e\u003cp\u003eStandardize sampling time, control choice, and downstream analysis thresholds so apparent differences in PNPLA2 reflect biology rather than handling. When interpreting PNPLA2, it is often useful to decide early whether the main question is overall abundance, compartmental enrichment, or context-dependent redistribution.\u003c\/p\u003e\u003cp\u003eFor multi-run studies, a shared reference condition can keep PNPLA2 trends easier to compare across datasets. That kind of consistency is especially helpful when follow-up work expands to new perturbations, model systems, or longitudinal collections.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"20 µl","offer_id":57578011853145,"sku":"F3255-20UL","price":149.0,"currency_code":"EUR","in_stock":true},{"title":"100 µl","offer_id":57578011885913,"sku":"F3255-100UL","price":319.0,"currency_code":"EUR","in_stock":true},{"title":"2 × 100 µl","offer_id":57578011918681,"sku":"F3255-2X100UL","price":479.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/F3255-IF.png?v=1773601064","url":"https:\/\/absource.de\/products\/pnpla2-antibody-sc-f3255","provider":"Absource Diagnostics","version":"1.0","type":"link"}