{"product_id":"pr-171-carfilzomib-s2853","title":"PR-171 (Carfilzomib)","description":"\u003cp\u003e\u003cstrong\u003ePR-171 (Carfilzomib)\u003c\/strong\u003e is an inhibitor of Proteasome used in studies of Apoptosis and Autophagy and related signaling programs. In practice, this places the compound in experiments that measure caspase-associated cell-death signaling and survival decisions and autophagic flux, lysosomal turnover, and stress adaptation in apoptosis, autophagy, and cancer models.\u003c\/p\u003e\n\n\u003cp\u003eBy inhibiting Proteasome, PR-171 (Carfilzomib) can be used to examine caspase-associated cell-death signaling and survival decisions and autophagic flux, lysosomal turnover, and stress adaptation. The protease annotation adds relevance to protease-activity, cleavage, and substrate-processing assays, together with downstream-response mapping in the same experimental setting. In apoptosis, autophagy, and cancer models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.\u003c\/p\u003e\n\n\u003ch2\u003eResearch Applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eTarget-focused assays involving Proteasome\u003c\/li\u003e\n\u003cli\u003ePathway perturbation studies connected to Apoptosis and Autophagy and related signaling programs\u003c\/li\u003e\n\u003cli\u003eConcentration-response inhibition and target-dependence studies\u003c\/li\u003e\n\u003cli\u003eProtease-activity, cleavage, and substrate-processing assays\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003eOverall, PR-171 (Carfilzomib) is appropriate when a defined chemical perturbant is needed to connect Proteasome with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in apoptosis, autophagy, and cancer models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"5 mg","offer_id":57805790183769,"sku":"S2853-5MG","price":167.0,"currency_code":"EUR","in_stock":true},{"title":"50 mg","offer_id":57805790216537,"sku":"S2853-50MG","price":560.0,"currency_code":"EUR","in_stock":true},{"title":"200 mg","offer_id":57805790249305,"sku":"S2853-200MG","price":953.0,"currency_code":"EUR","in_stock":true},{"title":"1 g","offer_id":57805790282073,"sku":"S2853-1G","price":1936.0,"currency_code":"EUR","in_stock":true},{"title":"1 ml (10mM\/DMSO)","offer_id":57805790314841,"sku":"S2853-1ML\/DMSO","price":390.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/carfilzomib-PR-171-chemical-structure-s2853.gif?v=1776175822","url":"https:\/\/absource.de\/products\/pr-171-carfilzomib-s2853","provider":"Absource Diagnostics","version":"1.0","type":"link"}