{"product_id":"prexasertib-ly2606368-dihydrochloride-s7178","title":"Prexasertib (LY2606368)Dihydrochloride","description":"\u003cp\u003e\u003cstrong\u003ePrexasertib (LY2606368)Dihydrochloride\u003c\/strong\u003e is an inhibitor of CHK1 and CHK2 and related targets used in studies of DNA Damage Response. It is especially relevant in cancer, cell cycle, and cell signaling models, where defined compound exposure can be linked to checkpoint activation, DNA repair, and genome-stability control.\u003c\/p\u003e\n\n\u003cp\u003eBy inhibiting CHK1 and CHK2 and related targets, Prexasertib (LY2606368)Dihydrochloride can be used to examine checkpoint activation, DNA repair, and genome-stability control. The kinase annotation adds relevance to biochemical kinase assays, phospho-signaling studies, and selectivity profiling, together with downstream-response mapping in the same experimental setting. In cancer, cell cycle, and cell signaling models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.\u003c\/p\u003e\n\n\u003ch2\u003eResearch Applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eTarget-focused assays involving CHK1 and CHK2 and related targets\u003c\/li\u003e\n\u003cli\u003ePathway perturbation studies connected to DNA Damage Response\u003c\/li\u003e\n\u003cli\u003eConcentration-response inhibition and target-dependence studies\u003c\/li\u003e\n\u003cli\u003eBiochemical kinase assays, phospho-signaling studies, and selectivity profiling\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003eOverall, Prexasertib (LY2606368)Dihydrochloride is appropriate when a defined chemical perturbant is needed to connect CHK1 and CHK2 and related targets with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in cancer, cell cycle, and cell signaling models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"2 mg","offer_id":57809461838169,"sku":"S7178-2MG","price":144.0,"currency_code":"EUR","in_stock":true},{"title":"5 mg","offer_id":57809461870937,"sku":"S7178-5MG","price":262.0,"currency_code":"EUR","in_stock":true},{"title":"25 mg","offer_id":57809461903705,"sku":"S7178-25MG","price":776.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/ly2606368-chemical-structure-s7178.gif?v=1776201035","url":"https:\/\/absource.de\/products\/prexasertib-ly2606368-dihydrochloride-s7178","provider":"Absource Diagnostics","version":"1.0","type":"link"}