{"product_id":"ps1-antibody-sc-f3873","title":"Presenilin 1\/PS-1 Antibody","description":"\u003ch2\u003eAbout the Target\u003c\/h2\u003e\u003cp\u003ePS1 is a target of interest in many antibody-based workflows. Presenilin 1 (PSEN1) is a transmembrane protein belonging to the presenilin family and is composed of 467 amino acids, sharing approximately 65% sequence similarity with presenilin 2 (PSEN2). Structurally, PSEN1 contains nine transmembrane domains interconnected by hydrophilic loops that extend into either the extracellular space or the cytosol. Depending on the literature source, PS1 may also be discussed as Presenilin 1\/PS-1 and AD3.\u003c\/p\u003e\u003cp\u003eReported cellular context includes cell membrane, cell projection, endoplasmic reticulum, and endosome, which can matter when signal is compared across treatments or changing cell states. Following PS1 across matched perturbations can help separate abundance effects from shifts in localization, complex assembly, or pathway state.\u003c\/p\u003e\u003ch2\u003eResearch Context\u003c\/h2\u003e\u003cp\u003ePS1 is commonly interpreted in the context of neuroscience, metabolism, and developmental biology research, and readouts are often stronger when a study separates expression changes from compartment-level redistribution. When reported signal spans cell membrane, cell projection, and endoplasmic reticulum, a defined reference condition can make comparisons more interpretable across perturbations, passages, or replicate sets.\u003c\/p\u003e\u003cp\u003eConsider these angles when interpreting target-level changes:\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eapparent redistribution between cell membrane, cell projection, and endoplasmic reticulum across matched conditions\u003c\/li\u003e\n\u003cli\u003ecompartment-specific patterns relevant to neuronal polarity, transport, or synaptic context\u003c\/li\u003e\n\u003cli\u003eresponses linked to nutrient status, mitochondrial state, or metabolic rewiring\u003c\/li\u003e\n\u003cli\u003estage-dependent patterns during differentiation, morphogenesis, or lineage commitment\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eVariant Considerations\u003c\/h2\u003e\u003cp\u003eIf your project spans exploratory questions, the regular version offers a balanced option for establishing baseline signal behavior for PS1. This can help when protocols evolve over time and the goal is to compare experiments using a stable reference workflow.\u003c\/p\u003e\u003cp\u003eStandardize sampling time, control choice, and downstream analysis thresholds so apparent differences in PS1 reflect biology rather than handling. When interpreting PS1, it is often useful to decide early whether the main question is overall abundance, compartmental enrichment, or context-dependent redistribution.\u003c\/p\u003e\u003cp\u003eFor multi-run studies, a shared reference condition can keep PS1 trends easier to compare across datasets. That kind of consistency is especially helpful when follow-up work expands to new perturbations, model systems, or longitudinal collections.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"20 µl","offer_id":57578050847065,"sku":"F3873-20UL","price":139.0,"currency_code":"EUR","in_stock":true},{"title":"100 µl","offer_id":57578050879833,"sku":"F3873-100UL","price":329.0,"currency_code":"EUR","in_stock":true},{"title":"2 × 100 µl","offer_id":57578050912601,"sku":"F3873-2X100UL","price":489.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/F3873-wb.gif?v=1773601540","url":"https:\/\/absource.de\/products\/ps1-antibody-sc-f3873","provider":"Absource Diagnostics","version":"1.0","type":"link"}