{"product_id":"psmd14-antibody-sc-f1105","title":"PSMD14 Antibody","description":"\u003ch2\u003eAbout the Target\u003c\/h2\u003e\u003cp\u003eThe oncogene PSMD14, also known as POH1 or Rpn11 (proteasome 26 S subunit, non-ATPase regulatory 14), is a deubiquitinating enzyme within the 19S proteasomal subunit. It plays a critical role in various physiological and pathological processes, including DNA damage repair, tumor formation, and inflammation. It releases polyubiquitin chains from polyubiquitinated protein substrates of the proteasome, particularly those with K63-linked ubiquitin chains.\u003c\/p\u003e\u003cp\u003eReported cellular context includes proteasome, which can matter when signal is compared across treatments or changing cell states. Following PSMD14 across matched perturbations can help separate abundance effects from shifts in localization, complex assembly, or pathway state.\u003c\/p\u003e\u003ch2\u003eResearch Context\u003c\/h2\u003e\u003cp\u003ePSMD14 is commonly interpreted in the context of cancer, apoptosis, and autophagy research, and readouts are often stronger when a study separates expression changes from compartment-level redistribution. When reported signal spans proteasome, a defined reference condition can make comparisons more interpretable across perturbations, passages, or replicate sets.\u003c\/p\u003e\u003cp\u003eConsider these angles when interpreting target-level changes:\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003esignal enrichment within proteasome relative to the broader cellular background\u003c\/li\u003e\n\u003cli\u003echanges associated with proliferative state, oncogenic signaling, or treatment response\u003c\/li\u003e\n\u003cli\u003eseparation of survival-associated changes from stress or death-associated readouts\u003c\/li\u003e\n\u003cli\u003einterpretation alongside flux, cargo handling, or lysosomal context\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eVariant Considerations\u003c\/h2\u003e\u003cp\u003eIf your project spans exploratory questions, the regular version offers a balanced option for establishing baseline signal behavior for PSMD14. This can help when protocols evolve over time and the goal is to compare experiments using a stable reference workflow.\u003c\/p\u003e\u003cp\u003eStandardize sampling time, control choice, and downstream analysis thresholds so apparent differences in PSMD14 reflect biology rather than handling. When interpreting PSMD14, it is often useful to decide early whether the main question is overall abundance, compartmental enrichment, or context-dependent redistribution.\u003c\/p\u003e\u003cp\u003eFor multi-run studies, a shared reference condition can keep PSMD14 trends easier to compare across datasets. That kind of consistency is especially helpful when follow-up work expands to new perturbations, model systems, or longitudinal collections.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"20 µl","offer_id":57577614377305,"sku":"F1105-20UL","price":149.0,"currency_code":"EUR","in_stock":true},{"title":"100 µl","offer_id":57577614410073,"sku":"F1105-100UL","price":329.0,"currency_code":"EUR","in_stock":true},{"title":"2 × 100 µl","offer_id":57577614442841,"sku":"F1105-2X100UL","price":489.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/F1105-IHC1.jpg?v=1773599293","url":"https:\/\/absource.de\/products\/psmd14-antibody-sc-f1105","provider":"Absource Diagnostics","version":"1.0","type":"link"}