{"product_id":"px-478-dihydrochloride-s7612","title":"PX-478 Dihydrochloride","description":"\u003cp\u003e\u003cstrong\u003ePX-478 Dihydrochloride\u003c\/strong\u003e is an inhibitor of HIF used in studies of Apoptosis. It is especially relevant in angiogenesis, apoptosis, and cancer models, where defined compound exposure can be linked to caspase-associated cell-death signaling and survival decisions.\u003c\/p\u003e\n\n\u003cp\u003eBy inhibiting HIF, PX-478 Dihydrochloride can be used to examine caspase-associated cell-death signaling and survival decisions. The signaling pathway modulator annotation adds relevance to pathway-reporter and mechanistic-phenotyping studies, together with downstream-response mapping in the same experimental setting. In angiogenesis, apoptosis, and cancer models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.\u003c\/p\u003e\n\n\u003ch2\u003eResearch Applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eTarget-focused assays involving HIF\u003c\/li\u003e\n\u003cli\u003ePathway perturbation studies connected to Apoptosis\u003c\/li\u003e\n\u003cli\u003eConcentration-response inhibition and target-dependence studies\u003c\/li\u003e\n\u003cli\u003ePathway-reporter and mechanistic-phenotyping studies\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003eOverall, PX-478 Dihydrochloride is appropriate when a defined chemical perturbant is needed to connect HIF with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in angiogenesis, apoptosis, and cancer models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"Selleck \/ 5 × 1 mg","offer_id":57809500766553,"sku":"S7612-5X1MG","price":144.0,"currency_code":"EUR","in_stock":true},{"title":"Selleck \/ 25 mg","offer_id":57809500799321,"sku":"S7612-25MG","price":468.0,"currency_code":"EUR","in_stock":true},{"title":"Selleck \/ 100 mg","offer_id":57809500832089,"sku":"S7612-100MG","price":979.0,"currency_code":"EUR","in_stock":true},{"title":"Selleck \/ 1 g","offer_id":57809500864857,"sku":"S7612-1G","price":2938.0,"currency_code":"EUR","in_stock":true},{"title":"Capsid \/ 25 mg","offer_id":58478913749337,"sku":"C12815-25MG","price":349.0,"currency_code":"EUR","in_stock":true},{"title":"Capsid \/ 100 mg","offer_id":58478913782105,"sku":"C12815-100MG","price":731.0,"currency_code":"EUR","in_stock":true},{"title":"Capsid \/ 1 g","offer_id":58478913814873,"sku":"C12815-1G","price":2195.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/px-478-2hcl-chemical-structure-s7612.gif?v=1776201618","url":"https:\/\/absource.de\/products\/px-478-dihydrochloride-s7612","provider":"Absource Diagnostics","version":"1.0","type":"link"}