{"product_id":"qnz-evp4593-s4902","title":"QNZ (EVP4593)","description":"\u003cp\u003e\u003cstrong\u003eQNZ (EVP4593)\u003c\/strong\u003e is an inhibitor of NF-kB and TNF-alpha used in studies of NF-kB Signaling and Immune Signaling. It is especially relevant when investigators need a named chemical input and interpretable readouts connected to inflammatory transcriptional control and stress-responsive survival signaling and cytokine-mediated signaling and inflammatory effector responses in immunology and inflammation models.\u003c\/p\u003e\n\n\u003cp\u003eBy inhibiting NF-kB and TNF-alpha, QNZ (EVP4593) can be used to examine inflammatory transcriptional control and stress-responsive survival signaling and cytokine-mediated signaling and inflammatory effector responses. The signaling pathway modulator annotation adds relevance to pathway-reporter and mechanistic-phenotyping studies, together with downstream-response mapping in the same experimental setting. In immunology and inflammation models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.\u003c\/p\u003e\n\n\u003ch2\u003eResearch Applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eTarget-focused assays involving NF-kB and TNF-alpha\u003c\/li\u003e\n\u003cli\u003ePathway perturbation studies connected to NF-kB Signaling and Immune Signaling\u003c\/li\u003e\n\u003cli\u003eConcentration-response inhibition and target-dependence studies\u003c\/li\u003e\n\u003cli\u003ePathway-reporter and mechanistic-phenotyping studies\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003eOverall, QNZ (EVP4593) is appropriate when a defined chemical perturbant is needed to connect NF-kB and TNF-alpha with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in immunology and inflammation models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"Selleck \/ 5 mg","offer_id":57809129963865,"sku":"S4902-5MG","price":144.0,"currency_code":"EUR","in_stock":true},{"title":"Selleck \/ 25 mg","offer_id":57809129996633,"sku":"S4902-25MG","price":363.0,"currency_code":"EUR","in_stock":true},{"title":"Selleck \/ 1 g","offer_id":57809130029401,"sku":"S4902-1G","price":2938.0,"currency_code":"EUR","in_stock":true},{"title":"Selleck \/ 1 ml (10mM\/DMSO)","offer_id":57809130062169,"sku":"S4902-1ML\/DMSO","price":193.0,"currency_code":"EUR","in_stock":true},{"title":"Capsid \/ 5 mg","offer_id":58478698889561,"sku":"C10540-5MG","price":108.0,"currency_code":"EUR","in_stock":true},{"title":"Capsid \/ 25 mg","offer_id":58478698922329,"sku":"C10540-25MG","price":271.0,"currency_code":"EUR","in_stock":true},{"title":"Capsid \/ 1 g","offer_id":58478698955097,"sku":"C10540-1G","price":2195.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/QNZ-chemical-structure-s4902.gif?v=1776197262","url":"https:\/\/absource.de\/products\/qnz-evp4593-s4902","provider":"Absource Diagnostics","version":"1.0","type":"link"}