{"product_id":"rel-antibody-sc-f1386","title":"c-Rel Antibody","description":"\u003ch2\u003eAbout the Target\u003c\/h2\u003e\u003cp\u003ec-Rel is a unique member of the NF-κB transcription factor family, encoded by the REL gene in humans, predominantly expressed in B and T cells. It plays a crucial role in lymphoid cell growth, survival, and differentiation. Structurally, c-Rel contains an N-terminal Rel homology domain (RHD) for DNA-binding and dimerization, and a C-terminal transcriptional activation domain (TAD). c-Rel forms dimers with other NF-κB subunits like p50 or RelA and activates transcription of anti-apoptotic genes such as Bcl-xL. Depending on the literature source, REL may also be discussed as c-Rel.\u003c\/p\u003e\u003cp\u003eReported cellular context includes nucleus, which can matter when signal is compared across treatments or changing cell states. Following REL across matched perturbations can help separate abundance effects from shifts in localization, complex assembly, or pathway state.\u003c\/p\u003e\u003ch2\u003eResearch Context\u003c\/h2\u003e\u003cp\u003eREL is commonly interpreted in the context of immunology and inflammation research, and readouts are often stronger when a study separates expression changes from compartment-level redistribution. When reported signal spans nucleus, a defined reference condition can make comparisons more interpretable across perturbations, passages, or replicate sets.\u003c\/p\u003e\u003cp\u003eConsider these angles when interpreting target-level changes:\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003esignal enrichment within nucleus relative to the broader cellular background\u003c\/li\u003e\n\u003cli\u003econtext differences tied to immune-cell state, activation, or lineage composition\u003c\/li\u003e\n\u003cli\u003eresponses associated with cytokine exposure, inflammatory tone, or tissue stress\u003c\/li\u003e\n\u003cli\u003eco-patterning with orthogonal markers and control conditions that clarify pathway state\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eVariant Considerations\u003c\/h2\u003e\u003cp\u003eIf your project spans exploratory questions, the regular version offers a balanced option for establishing baseline signal behavior for REL. This can help when protocols evolve over time and the goal is to compare experiments using a stable reference workflow.\u003c\/p\u003e\u003cp\u003eStandardize sampling time, control choice, and downstream analysis thresholds so apparent differences in REL reflect biology rather than handling. When interpreting REL, it is often useful to decide early whether the main question is overall abundance, compartmental enrichment, or context-dependent redistribution.\u003c\/p\u003e\u003cp\u003eFor multi-run studies, a shared reference condition can keep REL trends easier to compare across datasets. That kind of consistency is especially helpful when follow-up work expands to new perturbations, model systems, or longitudinal collections.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"20 µl","offer_id":57577716613465,"sku":"F1386-20UL","price":169.0,"currency_code":"EUR","in_stock":true},{"title":"100 µl","offer_id":57577716646233,"sku":"F1386-100UL","price":399.0,"currency_code":"EUR","in_stock":true},{"title":"2 × 100 µl","offer_id":57577716679001,"sku":"F1386-2X100UL","price":599.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/F1386-IF.png?v=1773599678","url":"https:\/\/absource.de\/products\/rel-antibody-sc-f1386","provider":"Absource Diagnostics","version":"1.0","type":"link"}