{"product_id":"ron-antibody-sc-f3215","title":"RON Antibody","description":"\u003ch2\u003eAbout the Target\u003c\/h2\u003e\u003cp\u003eRON (Recepteur d’Origine Nantais), also known as MST1R, is a receptor tyrosine kinase in the MET proto-oncogene family, predominantly expressed on epithelial cells. It is initially synthesized as a single-chain glycosylated precursor and undergoes proteolytic cleavage to form a functional heterodimer: an extracellular α-chain and a transmembrane β-chain that houses the intracellular tyrosine kinase domain. Depending on the literature source, RON may also be discussed as CD136 and PTK8.\u003c\/p\u003e\u003cp\u003eReported cellular context includes membrane, which can matter when signal is compared across treatments or changing cell states. Following RON across matched perturbations can help separate abundance effects from shifts in localization, complex assembly, or pathway state.\u003c\/p\u003e\u003ch2\u003eResearch Context\u003c\/h2\u003e\u003cp\u003eRON is commonly interpreted in the context of cancer, immunology, and developmental biology research, and readouts are often stronger when a study separates expression changes from compartment-level redistribution. When reported signal spans membrane, a defined reference condition can make comparisons more interpretable across perturbations, passages, or replicate sets.\u003c\/p\u003e\u003cp\u003eConsider these angles when interpreting target-level changes:\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003esignal enrichment within membrane relative to the broader cellular background\u003c\/li\u003e\n\u003cli\u003echanges associated with proliferative state, oncogenic signaling, or treatment response\u003c\/li\u003e\n\u003cli\u003econtext differences tied to immune-cell state, activation, or lineage composition\u003c\/li\u003e\n\u003cli\u003estage-dependent patterns during differentiation, morphogenesis, or lineage commitment\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eVariant Considerations\u003c\/h2\u003e\u003cp\u003eIf your project spans exploratory questions, the regular version offers a balanced option for establishing baseline signal behavior for RON. This can help when protocols evolve over time and the goal is to compare experiments using a stable reference workflow.\u003c\/p\u003e\u003cp\u003eStandardize sampling time, control choice, and downstream analysis thresholds so apparent differences in RON reflect biology rather than handling. When interpreting RON, it is often useful to decide early whether the main question is overall abundance, compartmental enrichment, or context-dependent redistribution.\u003c\/p\u003e\u003cp\u003eFor multi-run studies, a shared reference condition can keep RON trends easier to compare across datasets. That kind of consistency is especially helpful when follow-up work expands to new perturbations, model systems, or longitudinal collections.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"20 µl","offer_id":57578009330009,"sku":"F3215-20UL","price":149.0,"currency_code":"EUR","in_stock":true},{"title":"100 µl","offer_id":57578009362777,"sku":"F3215-100UL","price":359.0,"currency_code":"EUR","in_stock":true},{"title":"2 × 100 µl","offer_id":57578009395545,"sku":"F3215-2X100UL","price":539.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/F3215-wb.gif?v=1773601026","url":"https:\/\/absource.de\/products\/ron-antibody-sc-f3215","provider":"Absource Diagnostics","version":"1.0","type":"link"}