{"product_id":"rs-127445-s2698","title":"RS-127445","description":"\u003cp\u003e\u003cstrong\u003eRS-127445\u003c\/strong\u003e is an antagonist of 5-HT Receptors used in studies of GPCR Signaling and Neurotransmission. It is especially relevant in neuroscience models, where defined compound exposure can be linked to receptor-driven second-messenger signaling and desensitization dynamics and synaptic signaling, receptor activity, and neuronal excitability.\u003c\/p\u003e\n\n\u003cp\u003eBy blocking 5-HT Receptors, RS-127445 can be used to examine receptor-driven second-messenger signaling and desensitization dynamics and synaptic signaling, receptor activity, and neuronal excitability. The gpcr annotation adds relevance to GPCR pharmacology, ligand-binding, and signaling assays, together with downstream-response mapping in the same experimental setting. In neuroscience models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.\u003c\/p\u003e\n\n\u003ch2\u003eResearch Applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eTarget-focused assays involving 5-HT Receptors\u003c\/li\u003e\n\u003cli\u003ePathway perturbation studies connected to GPCR Signaling and Neurotransmission\u003c\/li\u003e\n\u003cli\u003eReceptor-blockade and ligand-competition studies\u003c\/li\u003e\n\u003cli\u003eGPCR pharmacology, ligand-binding, and signaling assays\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003eOverall, RS-127445 is appropriate when a defined chemical perturbant is needed to connect 5-HT Receptors with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in neuroscience models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"Selleck \/ 5 mg","offer_id":57805702136153,"sku":"S2698-5MG","price":68.0,"currency_code":"EUR","in_stock":true},{"title":"Selleck \/ 10 mg","offer_id":57805702168921,"sku":"S2698-10MG","price":108.0,"currency_code":"EUR","in_stock":true},{"title":"Selleck \/ 50 mg","offer_id":57805702201689,"sku":"S2698-50MG","price":461.0,"currency_code":"EUR","in_stock":true},{"title":"Capsid \/ 5 mg","offer_id":58478553563481,"sku":"C08791-5MG","price":51.0,"currency_code":"EUR","in_stock":true},{"title":"Capsid \/ 10 mg","offer_id":58478553596249,"sku":"C17012-10MG","price":81.0,"currency_code":"EUR","in_stock":true},{"title":"Capsid \/ 50 mg","offer_id":58478553629017,"sku":"C08791-50MG","price":344.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/rs-127445-chemical-structure-s2698.gif?v=1776175551","url":"https:\/\/absource.de\/products\/rs-127445-s2698","provider":"Absource Diagnostics","version":"1.0","type":"link"}