{"product_id":"rucaparib-ag-014699-s4948","title":"Rucaparib (AG-014699)","description":"\u003cp\u003e\u003cstrong\u003eRucaparib (AG-014699)\u003c\/strong\u003e is an inhibitor of PARP1 used in studies of DNA Damage Response. It is especially relevant when investigators need a named chemical input and interpretable readouts connected to checkpoint activation, DNA repair, and genome-stability control in cancer and dna damage \/ repair models.\u003c\/p\u003e\n\n\u003cp\u003eBy inhibiting PARP1, Rucaparib (AG-014699) can be used to examine checkpoint activation, DNA repair, and genome-stability control. The enzyme annotation adds relevance to enzyme-activity assays, substrate-conversion studies, and mechanism profiling, together with downstream-response mapping in the same experimental setting. In cancer and dna damage \/ repair models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.\u003c\/p\u003e\n\n\u003ch2\u003eResearch Applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eTarget-focused assays involving PARP1\u003c\/li\u003e\n\u003cli\u003ePathway perturbation studies connected to DNA Damage Response\u003c\/li\u003e\n\u003cli\u003eConcentration-response inhibition and target-dependence studies\u003c\/li\u003e\n\u003cli\u003eEnzyme-activity assays, substrate-conversion studies, and mechanism profiling\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003eOverall, Rucaparib (AG-014699) is appropriate when a defined chemical perturbant is needed to connect PARP1 with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in cancer and dna damage \/ repair models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"5 mg","offer_id":57809135731033,"sku":"S4948-5MG","price":144.0,"currency_code":"EUR","in_stock":true},{"title":"25 mg","offer_id":57809135763801,"sku":"S4948-25MG","price":350.0,"currency_code":"EUR","in_stock":true},{"title":"100 mg","offer_id":57809135796569,"sku":"S4948-100MG","price":874.0,"currency_code":"EUR","in_stock":true},{"title":"1 g","offer_id":57809135829337,"sku":"S4948-1G","price":3901.0,"currency_code":"EUR","in_stock":true},{"title":"1 ml (10mM\/DMSO)","offer_id":57809135862105,"sku":"S4948-1ML\/DMSO","price":193.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/s4948-rucaparib-chemical-structure.gif?v=1776197322","url":"https:\/\/absource.de\/products\/rucaparib-ag-014699-s4948","provider":"Absource Diagnostics","version":"1.0","type":"link"}