{"product_id":"salermide-s8460","title":"Salermide","description":"\u003cp\u003e\u003cstrong\u003eSalermide\u003c\/strong\u003e is an inhibitor of Sirtuins used in studies of DNA Damage Response and Epigenetic Regulation. It is especially relevant when investigators need a named chemical input and interpretable readouts connected to checkpoint activation, DNA repair, and genome-stability control and chromatin-state control, histone modification, and transcriptional regulation in aging, cancer, and dna damage \/ repair models.\u003c\/p\u003e\n\n\u003cp\u003eBy inhibiting Sirtuins, Salermide can be used to examine checkpoint activation, DNA repair, and genome-stability control and chromatin-state control, histone modification, and transcriptional regulation. The epigenetic regulator annotation adds relevance to chromatin, epigenetic, and gene-expression profiling, together with downstream-response mapping in the same experimental setting. In aging, cancer, and dna damage \/ repair models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.\u003c\/p\u003e\n\n\u003ch2\u003eResearch Applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eTarget-focused assays involving Sirtuins\u003c\/li\u003e\n\u003cli\u003ePathway perturbation studies connected to DNA Damage Response and Epigenetic Regulation\u003c\/li\u003e\n\u003cli\u003eConcentration-response inhibition and target-dependence studies\u003c\/li\u003e\n\u003cli\u003eChromatin, epigenetic, and gene-expression profiling\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003eOverall, Salermide is appropriate when a defined chemical perturbant is needed to connect Sirtuins with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in aging, cancer, and dna damage \/ repair models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"10 mg","offer_id":57809612308825,"sku":"S8460-10MG","price":95.0,"currency_code":"EUR","in_stock":true},{"title":"50 mg","offer_id":57809612341593,"sku":"S8460-50MG","price":390.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/salermide-chemical-structure-S8460.gif?v=1776202741","url":"https:\/\/absource.de\/products\/salermide-s8460","provider":"Absource Diagnostics","version":"1.0","type":"link"}