{"product_id":"sappanone-a-e0526","title":"sappanone A","description":"\u003cp\u003e\u003cstrong\u003esappanone A\u003c\/strong\u003e is an activator of p38 MAPK and NRF2 and related targets used in studies of MAPK \/ ERK Signaling and NF-kB Signaling and related signaling programs. It is especially relevant when investigators need a named chemical input and interpretable readouts connected to mitogenic kinase cascades, proliferation control, and differentiation-linked signaling and inflammatory transcriptional control and stress-responsive survival signaling in cell signaling, immunology, and inflammation models.\u003c\/p\u003e\n\n\u003cp\u003eBy activating p38 MAPK and NRF2 and related targets, sappanone A can be used to examine mitogenic kinase cascades, proliferation control, and differentiation-linked signaling and inflammatory transcriptional control and stress-responsive survival signaling. The signaling pathway modulator annotation adds relevance to pathway-reporter and mechanistic-phenotyping studies, together with downstream-response mapping in the same experimental setting. In cell signaling, immunology, and inflammation models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.\u003c\/p\u003e\n\n\u003ch2\u003eResearch Applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eTarget-focused assays involving p38 MAPK and NRF2 and related targets\u003c\/li\u003e\n\u003cli\u003ePathway perturbation studies connected to MAPK \/ ERK Signaling and NF-kB Signaling and related signaling programs\u003c\/li\u003e\n\u003cli\u003eGain-of-function pathway-activation studies\u003c\/li\u003e\n\u003cli\u003ePathway-reporter and mechanistic-phenotyping studies\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003eOverall, sappanone A is appropriate when a defined chemical perturbant is needed to connect p38 MAPK and NRF2 and related targets with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in cell signaling, immunology, and inflammation models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"5 mg","offer_id":57804276564313,"sku":"E0526-5MG","price":144.0,"currency_code":"EUR","in_stock":true},{"title":"25 mg","offer_id":57804276597081,"sku":"E0526-25MG","price":363.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/e0526-sappanone-a-chemical-structure.gif?v=1776166143","url":"https:\/\/absource.de\/products\/sappanone-a-e0526","provider":"Absource Diagnostics","version":"1.0","type":"link"}