{"product_id":"sar407899-hydrochloride-e2385","title":"SAR407899 hydrochloride","description":"\u003cp\u003e\u003cstrong\u003eSAR407899 hydrochloride\u003c\/strong\u003e is an inhibitor of Rho GTPases and ROCK used in studies of target-focused biology. In practice, this places the compound in experiments that measure annotated target biology and downstream cellular responses in cancer, cardiovascular, and cell cycle models.\u003c\/p\u003e\n\n\u003cp\u003eBy inhibiting Rho GTPases and ROCK, SAR407899 hydrochloride can be used to examine annotated target biology and downstream cellular responses. That positioning is consistent with concentration-response inhibition and target-dependence studies and with follow-up studies that compare concentration-dependent responses across orthogonal assay formats. In cancer, cardiovascular, and cell cycle models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.\u003c\/p\u003e\n\n\u003ch2\u003eResearch Applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eTarget-focused assays involving Rho GTPases and ROCK\u003c\/li\u003e\n\u003cli\u003eConcentration-response inhibition and target-dependence studies\u003c\/li\u003e\n\u003cli\u003ePhenotypic profiling in cancer, cardiovascular, and cell cycle models\u003c\/li\u003e\n\u003cli\u003eCombination studies with orthogonal perturbagens\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003eOverall, SAR407899 hydrochloride is appropriate when a defined chemical perturbant is needed to connect Rho GTPases and ROCK with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in cancer, cardiovascular, and cell cycle models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"5 mg","offer_id":57804582682969,"sku":"E2385-5MG","price":144.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/e2385-sar407899-hydrochloride-chemical-structure.gif?v=1776167686","url":"https:\/\/absource.de\/products\/sar407899-hydrochloride-e2385","provider":"Absource Diagnostics","version":"1.0","type":"link"}