{"product_id":"sb203580-adezmapimod-s1076","title":"SB203580 (Adezmapimod)","description":"\u003cp\u003e\u003cstrong\u003eSB203580 (Adezmapimod)\u003c\/strong\u003e is an inhibitor of p38 MAPK used in studies of MAPK \/ ERK Signaling and Immune Signaling and related signaling programs. It is especially relevant when investigators need a named chemical input and interpretable readouts connected to mitogenic kinase cascades, proliferation control, and differentiation-linked signaling and cytokine-mediated signaling and inflammatory effector responses in autophagy, cancer, and cell signaling models.\u003c\/p\u003e\n\n\u003cp\u003eBy inhibiting p38 MAPK, SB203580 (Adezmapimod) can be used to examine mitogenic kinase cascades, proliferation control, and differentiation-linked signaling and cytokine-mediated signaling and inflammatory effector responses. The kinase annotation adds relevance to biochemical kinase assays, phospho-signaling studies, and selectivity profiling, together with downstream-response mapping in the same experimental setting. In autophagy, cancer, and cell signaling models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.\u003c\/p\u003e\n\n\u003ch2\u003eResearch Applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eTarget-focused assays involving p38 MAPK\u003c\/li\u003e\n\u003cli\u003ePathway perturbation studies connected to MAPK \/ ERK Signaling and Immune Signaling and related signaling programs\u003c\/li\u003e\n\u003cli\u003eConcentration-response inhibition and target-dependence studies\u003c\/li\u003e\n\u003cli\u003eBiochemical kinase assays, phospho-signaling studies, and selectivity profiling\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003eOverall, SB203580 (Adezmapimod) is appropriate when a defined chemical perturbant is needed to connect p38 MAPK with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in autophagy, cancer, and cell signaling models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"25 mg","offer_id":57805213827417,"sku":"S1076-25MG","price":144.0,"currency_code":"EUR","in_stock":true},{"title":"1 g","offer_id":57805213860185,"sku":"S1076-1G","price":953.0,"currency_code":"EUR","in_stock":true},{"title":"1 ml (10mM\/DMSO)","offer_id":57805213892953,"sku":"S1076-1ML\/DMSO","price":193.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/SB-203580-chemical-structure-S1076.gif?v=1776172862","url":"https:\/\/absource.de\/products\/sb203580-adezmapimod-s1076","provider":"Absource Diagnostics","version":"1.0","type":"link"}