{"product_id":"sgi-1027-s7276","title":"SGI-1027","description":"\u003cp\u003e\u003cstrong\u003eSGI-1027\u003c\/strong\u003e is an inhibitor of DNA Methyltransferases and Transferases used in studies of Apoptosis and Epigenetic Regulation and related signaling programs. It is especially relevant in apoptosis, cancer, and epigenetics models, where defined compound exposure can be linked to caspase-associated cell-death signaling and survival decisions and chromatin-state control, histone modification, and transcriptional regulation.\u003c\/p\u003e\n\n\u003cp\u003eBy inhibiting DNA Methyltransferases and Transferases, SGI-1027 can be used to examine caspase-associated cell-death signaling and survival decisions and chromatin-state control, histone modification, and transcriptional regulation. The epigenetic regulator annotation adds relevance to chromatin, epigenetic, and gene-expression profiling, together with downstream-response mapping in the same experimental setting. In apoptosis, cancer, and epigenetics models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.\u003c\/p\u003e\n\n\u003ch2\u003eResearch Applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eTarget-focused assays involving DNA Methyltransferases and Transferases\u003c\/li\u003e\n\u003cli\u003ePathway perturbation studies connected to Apoptosis and Epigenetic Regulation and related signaling programs\u003c\/li\u003e\n\u003cli\u003eConcentration-response inhibition and target-dependence studies\u003c\/li\u003e\n\u003cli\u003eChromatin, epigenetic, and gene-expression profiling\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003eOverall, SGI-1027 is appropriate when a defined chemical perturbant is needed to connect DNA Methyltransferases and Transferases with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in apoptosis, cancer, and epigenetics models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"10 mg","offer_id":57809469243737,"sku":"S7276-10MG","price":144.0,"currency_code":"EUR","in_stock":true},{"title":"100 mg","offer_id":57809469276505,"sku":"S7276-100MG","price":953.0,"currency_code":"EUR","in_stock":true},{"title":"1 ml (10mM\/DMSO)","offer_id":57809469309273,"sku":"S7276-1ML\/DMSO","price":193.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/SGI-1027-chemical-structure-s7276.gif?v=1776201149","url":"https:\/\/absource.de\/products\/sgi-1027-s7276","provider":"Absource Diagnostics","version":"1.0","type":"link"}