{"product_id":"sis3-hydrochloride-s7959","title":"SIS3 Hydrochloride","description":"\u003cp\u003e\u003cstrong\u003eSIS3 Hydrochloride\u003c\/strong\u003e is an inhibitor of TGF-beta \/ Smad used in studies of MAPK \/ ERK Signaling and TGF-beta \/ Smad Signaling. It is especially relevant in cancer, cell signaling, and developmental biology models, where defined compound exposure can be linked to mitogenic kinase cascades, proliferation control, and differentiation-linked signaling and Smad-mediated transcription, differentiation, and fibrotic signaling.\u003c\/p\u003e\n\n\u003cp\u003eBy inhibiting TGF-beta \/ Smad, SIS3 Hydrochloride can be used to examine mitogenic kinase cascades, proliferation control, and differentiation-linked signaling and Smad-mediated transcription, differentiation, and fibrotic signaling. The signaling pathway modulator annotation adds relevance to pathway-reporter and mechanistic-phenotyping studies, together with downstream-response mapping in the same experimental setting. In cancer, cell signaling, and developmental biology models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.\u003c\/p\u003e\n\n\u003ch2\u003eResearch Applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eTarget-focused assays involving TGF-beta \/ Smad\u003c\/li\u003e\n\u003cli\u003ePathway perturbation studies connected to MAPK \/ ERK Signaling and TGF-beta \/ Smad Signaling\u003c\/li\u003e\n\u003cli\u003eConcentration-response inhibition and target-dependence studies\u003c\/li\u003e\n\u003cli\u003ePathway-reporter and mechanistic-phenotyping studies\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003eOverall, SIS3 Hydrochloride is appropriate when a defined chemical perturbant is needed to connect TGF-beta \/ Smad with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in cancer, cell signaling, and developmental biology models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"2 mg","offer_id":57809563189593,"sku":"S7959-2MG","price":144.0,"currency_code":"EUR","in_stock":true},{"title":"5 mg","offer_id":57809563222361,"sku":"S7959-5MG","price":242.0,"currency_code":"EUR","in_stock":true},{"title":"25 mg","offer_id":57809563255129,"sku":"S7959-25MG","price":685.0,"currency_code":"EUR","in_stock":true},{"title":"100 mg","offer_id":57809563287897,"sku":"S7959-100MG","price":1366.0,"currency_code":"EUR","in_stock":true},{"title":"1 g","offer_id":57809563320665,"sku":"S7959-1G","price":3921.0,"currency_code":"EUR","in_stock":true},{"title":"1 ml (10mM\/DMSO)","offer_id":57809563353433,"sku":"S7959-1ML\/DMSO","price":291.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/sis3-chemical-structure-s7959.gif?v=1776202119","url":"https:\/\/absource.de\/products\/sis3-hydrochloride-s7959","provider":"Absource Diagnostics","version":"1.0","type":"link"}